Evidence map›Paper›PMID 41150373›Full record

ArticleTropical medicine and infectious disease2025

Evaluation of Tuberculosis Preventive Treatment Uptake Among People Living with HIV in PEPFAR-Supported Facilities in Zimbabwe.

Collins Timire, Tawanda Mapuranga, Ronald T Ncube, Talent Maphosa, Sithabiso Dube, Nqobile Mlilo, Cynthia Chiteve, Selma Dar Berger, Owen Mugurungi, Fungai Kavenga and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tropical medicine and infectious disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Collins TimireInternational Union Against Tuberculosis and Lung Disease (The Union), 75001 Paris, France.ORCID 0000-0003-0997-9799
Tawanda MapurangaUnion Zimbabwe Trust, 261 Diamond Road, Westgate, Harare P.O. Box CY 550, Zimbabwe.ORCID 0009-0002-7785-4576
Ronald T NcubeUnion Zimbabwe Trust, 261 Diamond Road, Westgate, Harare P.O. Box CY 550, Zimbabwe.ORCID 0000-0003-4668-0868
Talent MaphosaDepartment of Health and Human Services, U.S. Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA.
Sithabiso DubeUnion Zimbabwe Trust, 261 Diamond Road, Westgate, Harare P.O. Box CY 550, Zimbabwe.
Nqobile MliloUnion Zimbabwe Trust, 261 Diamond Road, Westgate, Harare P.O. Box CY 550, Zimbabwe.
Cynthia ChiteveUnion Zimbabwe Trust, 261 Diamond Road, Westgate, Harare P.O. Box CY 550, Zimbabwe.
Selma Dar BergerInternational Union Against Tuberculosis and Lung Disease (The Union), 75001 Paris, France.
Owen MugurungiAIDS & TB Department, Ministry of Health and Child Care, Harare P.O. Box CY 1122, Zimbabwe.
Fungai KavengaAIDS & TB Department, Ministry of Health and Child Care, Harare P.O. Box CY 1122, Zimbabwe.
Tsitsi Mutasa-ApolloAIDS & TB Department, Ministry of Health and Child Care, Harare P.O. Box CY 1122, Zimbabwe.
Manners NcubeAIDS & TB Department, Ministry of Health and Child Care, Harare P.O. Box CY 1122, Zimbabwe.
Clorata GwanzuraAIDS & TB Department, Ministry of Health and Child Care, Harare P.O. Box CY 1122, Zimbabwe.
Macarthur CharlesDepartment of Health and Human Services, U.S. Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA.
Riitta A DlodloInternational Union Against Tuberculosis and Lung Disease (The Union), 75001 Paris, France.ORCID 0000-0002-3415-672X
Julia ErshovaDepartment of Health and Human Services, U.S. Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA.

Funding

President's Emergency Plan for AIDS Relief (PEPFAR) through the Centers for Disease Control and Prevention (CDC) NU2GGH002222
6 · The paper itself

Abstract

Tuberculosis preventive treatment (TPT) reduces the incidence of tuberculosis (TB) among people living with HIV (PLHIV), but its coverage remains suboptimal in most settings. We conducted a cross-sectional study to describe TPT uptake among PLHIV and factors influencing TPT initiation. Healthcare workers (HCWs) in selected facilities were trained and supported to strengthen TPT management among PLHIV, including children living with HIV (CLHIV). Of 1309 enrolled PLHIV, 1268 (97%) were eligible for TPT; 1078 (85%) initiated TPT, including 663/776 (86%) among those currently on ART and 415/492 (84%) among clients newly on ART. The major reasons for not starting TPT included stock-outs of TPT medicines, TB disease, and refusal of TPT, mostly by CLHIV and adults currently on ART. Optimal and sustained uptake of TPT can be achieved through ensuring uninterrupted stocks of TPT medicines, including shorter regimens and pediatric formulations, addressing knowledge deficits among HCWs, and improving demand for TPT by educating PLHIV and caregivers of CLHIV about the benefits and risks of TPT formulations.

Indexed as

childhood tuberculosiscollaborative TB-HIV servicesisoniazid preventive therapysub-Saharan AfricaTB infection

Identifiers

PMID41150373
PMCPMC12567572

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.