Evidence map›Paper›PMID 41150161›Full record

ArticleeLife2025

Newly trained navigation and verbal memory skills in humans elicit changes in task-related networks but not brain structure.

Li Zheng, Zachary Boogaart, Andrew McAvan, Joshua Garren, Stephanie G Doner, Bradley J Wilkes, Will Groves, Ece Yuksel, Lucia Cherep, Arne Ekstrom and 1 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07423923 (Representation of Spatiotemporal Information in Human Episodic Memory and Navigation), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07423923 early_phase1enrolling by invitationnot on this map

Representation of Spatiotemporal Information in Human Episodic Memory and Navigation

TypeinterventionalSponsorUniversity of ArizonaRan2025 to 2030Enrolled15ConditionsScopolamine or Placebo, Schema to Organize Memory or no SchemaArmsScopolamine
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. The Effect of Guided Imagery and Music withIranian journal of nursing and midwifery research
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Li ZhengDepartment of Psychology, University of Arizona, Tucson, United States.ORCID https://orcid.org/0000-0002-9358-4353
Zachary BoogaartThe University of Miami Miller School of Medicine, University of Miami, Coral Gables, United States.
Andrew McAvanDepartment of Psychology, University of Arizona, Tucson, United States.ORCID https://orcid.org/0000-0002-1253-884X
Joshua GarrenDepartment of Psychology, University of Arizona, Tucson, United States.
Stephanie G DonerDepartment of Psychology, University of Arizona, Tucson, United States.ORCID https://orcid.org/0000-0002-0338-5052
Bradley J WilkesDepartment of Applied Physiology & Kinesiology, University of Florida, Gainesville, United States.
Will GrovesDepartment of Psychology, University of Florida, Gainesville, United States.
Ece YukselDepartment of Psychology, University of Florida, Gainesville, United States.
Lucia CherepDepartment of Psychology, University of Arizona, Tucson, United States.
Arne EkstromDepartment of Psychology, University of Arizona, Tucson, United States.ORCID https://orcid.org/0000-0002-6812-2368
Steven M WeisbergDepartment of Psychology, University of Florida, Gainesville, United States.ORCID https://orcid.org/0000-0001-7003-6082

Funding

Advanced 3T for Structural and Functional Imaging at University of FloridaS10OD021726 · OD · UNIVERSITY OF FLORIDA · PI LONG, JOANNA R · 2017 to 2017
$2.0M
Critical Life Event Support for K01 NIA AwardeeK01AG070333 · NIA · UNIVERSITY OF FLORIDA · PI WEISBERG, STEVEN M · 2021 to 2025
$694k
Volumetric and connectivity measures of navigation and memory skill acquisitionR21NS120237 · NINDS · UNIVERSITY OF ARIZONA · PI EKSTROM, ARNE D, WEISBERG, STEVEN M · 2020 to 2020
$434k
Arizona Alzheimer's Consortium Pilot Project grant programNIA NIH HHS K01 AG070333NIH HHS K01AG070333-01NIH HHS R21NS120237-01NIH HHS S10 OD021726NINDS NIH HHS R21 NS120237
6 · The paper itself

Abstract

Training cognitive skills, such as remembering a list of words or navigating a new city, has important implications for everyday life. Yet, understanding what brain changes in humans underlies the acquisition of complex cognitive skills remains unresolved. Here, we developed and validated intensive multiweek interventions in which participants were randomly assigned training in either navigation or verbal memory. Healthy young participants (N=75) underwent structural and functional imaging prior to and following the training. Based on pre-registered and exploratory analyses, we did not find any evidence for changes to gross hippocampal or hippocampal subfield volume, cortical brain volume, or microstructural properties of major white matter tracts due to the training. In contrast, network-based analyses suggested changes in task-related informational connectivity, which occurred primarily between cortical areas and mostly involved putative cognitive control networks. These results suggest that cognitive interventions target more transient configurations in network connectivity rather than more durable structural changes.

Indexed as

BrainMemorySpatial NavigationAdolescentAdultCognitionFemaleHippocampusHumansMagnetic Resonance ImagingMaleYoung Adultbrain networkscognitive trainingfunctional connectivityhippocampushumannavigationneuroscienceverbal memory

Identifiers

PMID41150161
PMCPMC12563549

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.