Evidence map›Paper›PMID 41150061›Full record

ArticleVeterinary sciences2025

Extended Survival in a Dog with Primary Bone Hemangiosarcoma Following Treatment with Neoadjuvant Oncolytic Virotherapy and Standard of Care.

Courtney Labé, Andrea Chehadeh, Amber Winter, Sara Pracht, Kathy M Stuebner, Mitzi Lewellen, Bishoy Eskander, M Gerard O'Sullivan, Alexandru-Flaviu Tabaran, Christopher Ober and 6 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Courtney LabéDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.
Andrea ChehadehClinical Investigation Center, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.
Amber WinterClinical Investigation Center, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.
Sara PrachtClinical Investigation Center, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.
Kathy M StuebnerDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.
Mitzi LewellenDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.ORCID 0009-0005-9026-9883
Bishoy EskanderDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.
M Gerard O'SullivanAnimal Cancer Care and Research Program, University of Minnesota, St. Paul, MN 55108, USA.
Alexandru-Flaviu TabaranDepartment of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.ORCID 0000-0001-5744-0451
Christopher OberDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.ORCID 0000-0003-1491-6792
Michael S HensonDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.
Davis SeeligDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.
Steve J RussellDepartment of Molecular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Jaime F ModianoDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.ORCID 0000-0001-6398-7648
Shruthi NaikDepartment of Molecular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Kelly M MakielskiDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.ORCID 0000-0001-7878-2370

Funding

Molecular Signatures of Biologic Behavior in Pediatric OsteosarcomaK01OD031810 · OD · UNIVERSITY OF MINNESOTA · PI Kelly M Makielski · 2023 to 2026
$498k
(PQ3) Modulation of Osteosarcoma Biology by Inflammation and Immunity Defined through a ComparativeApproachR21CA208529 · NCI · UNIVERSITY OF MINNESOTA · PI MODIANO, JAIME F. · 2016 to 2017
$365k
Minnesota Partnership for Biotechnology and Medical Genomics 15.25NCI NIH HHS R21 CA208529NIH HHS 1K01OD031810-01NIH HHS K01 OD031810US Department of Defense Peer Reviewed Cancer Research Program CA 170218US Department of Defense Peer Reviewed Cancer Research Program CA 190276
6 · The paper itself

Abstract

A three year old male neutered mixed breed dog presented with a mass on the right carpus and accompanying lameness. A Jamshidi bone biopsy was performed, and histopathology results were consistent with a sarcoma. The dog received oncolytic virotherapy (OV) with vesicular stomatitis virus (VSV) as part of a clinical trial in dogs with osteosarcoma (OSA). Ten days after VSV treatment, the affected limb was amputated, and histopathology was consistent with intramedullary HSA. Considering the new diagnosis, standard doxorubicin chemotherapy was prescribed. With this combination of therapies, the dog had an extended survival of more than seven years and remains alive at the time of writing. This is the first case report documenting OV given in conjunction with the standard of care for canine appendicular HSA.

Indexed as

cancercaninecomparative oncologydogdoxorubicinhemangiosarcomaimmunotherapyosteosarcomavirotherapy

Identifiers

PMID41150061
PMCPMC12568109

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.