Evidence map›Paper›PMID 41149887›Full record

ArticleJournal of fungi (Basel, Switzerland)2025

The Diagnostic Challenge of a False-Positive Cryptococcal Antigen in Chronic Meningitis with Suspected Indolent CNS B-Cell Lymphoproliferative Neoplasm.

MohammadReza Rahimi Shahmirzadi, Melissa Fowler, Lise Bondy, Seth Climans, Jonathan Lau, Eric To, Yiannis Iordanous, Marilyn Phung, Fatimah AlMutawa, Jeff Fuller and 1 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of fungi (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

MohammadReza Rahimi ShahmirzadiDivision of Infectious Diseases, Western University, London, ON N6A 4V2, Canada.ORCID 0000-0002-2410-6788
Melissa FowlerDivision of Infectious Diseases, Western University, London, ON N6A 4V2, Canada.
Lise BondyDivision of Infectious Diseases, Western University, London, ON N6A 4V2, Canada.ORCID 0000-0003-1692-7217
Seth ClimansDepartment of Clinical Neurological Sciences, Western University, London, ON N6A 5W9, Canada.ORCID 0000-0002-4961-237X
Jonathan LauDepartment of Clinical Neurological Sciences, Western University, London, ON N6A 5W9, Canada.
Eric ToDivision of Hematology and Oncology, Western University, London, ON N6A 5W9, Canada.
Yiannis IordanousDepartment of Ophthalmology, Western University, London, ON N6A 4V2, Canada.ORCID 0009-0001-2437-7676
Marilyn PhungDepartment of Internal Medicine, Western University, London, ON N6A 5W9, Canada.ORCID 0000-0003-1498-2220
Fatimah AlMutawaDepartment of Pathology and Laboratory Medicine, Western University, London, ON N6A 5W9, Canada.ORCID 0000-0002-3978-1823
Jeff FullerDepartment of Pathology and Laboratory Medicine, Western University, London, ON N6A 5W9, Canada.
Michael SilvermanDivision of Infectious Diseases, Western University, London, ON N6A 4V2, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 47-year-old woman presented with a two-year history of progressive visual symptoms and headaches. Lumbar puncture revealed lymphocytic pleocytosis, elevated protein, low glucose, and a CSF CrAg titer of 1:256. She was treated empirically for cryptococcal meningitis with amphotericin B, flucytosine, and fluconazole for 15 months. Her symptoms persisted, and repeated CSF and serum CrAg, fungal cultures, and an extensive infectious workup were negative. CSF flow cytometry eventually demonstrated a monoclonal B-cell population suggestive of a lymphoproliferative process. Imaging, including MRI and PET scans, did not reveal systemic disease. A ventriculoperitoneal (VP) shunt was placed for symptom management. This case emphasizes the limitations of CrAg testing and the potential for false positives. It underscores the need for integrating clinical, laboratory, and imaging data when evaluating chronic meningitis.

Indexed as

B-cell lymphoproliferative neoplasmcase reportCryptococcusfalse-positivemeningitis

Identifiers

PMID41149887
PMCPMC12565529

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.