Evidence map›Paper›PMID 41149758›Full record

ArticleJournal of xenobiotics2025

Association Between Antibiotic Exposure and the Risk of Male Infertility: A Case-Control Study.

Friday E Okonofua, Lorretta Favour C Ntoimo, Titus A M Msagati, Oladiran Ayodeji, Michael Aziken, Akhere Omonkhua, Victor Ohenhen, Celestina Olafusi, Moses O Alfred

Abstract read
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In one paragraph

Article in Journal of xenobiotics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Friday E OkonofuaDepartment of Obstetrics and Gynaecology, University of Benin Teaching Hospital, University of Benin, Benin City 300213, Nigeria.
Lorretta Favour C NtoimoWomen's Health and Action Research Centre (WHARC), Benin City 300283, Nigeria.
Titus A M MsagatiInstitute for Nanotechnology and Water Sustainability, College of Science, Engineering and Technology, The Science Campus, University of South Africa, Corner Pioneer Avenue and Christiaan De Wet, Roodepoort, Johannesburg 1709, South Africa.ORCID 0000-0002-9621-5051
Oladiran AyodejiDepartment of Obstetrics and Gynaecology, University of Medical Sciences, Ilaje, Ondo 351104, Nigeria.ORCID 0000-0002-3006-5812
Michael AzikenDepartment of Obstetrics and Gynaecology, University of Benin Teaching Hospital, University of Benin, Benin City 300213, Nigeria.
Akhere OmonkhuaDepartment of Medical Biochemistry, School of Basic Medical Sciences, University of Benin, Benin City 300213, Nigeria.
Victor OhenhenDepartment of Obstetrics and Gynaecology, Central Hospital, Benin City 300102, Nigeria.ORCID 0000-0001-6311-7239
Celestina OlafusiDepartment of Biochemistry, University of Medical Sciences, Ilaje, Ondo 351104, Nigeria.ORCID 0009-0009-7468-0129
Moses O AlfredDepartment of Chemical Sciences, Redeemer's University, Ede 232101, Nigeria.ORCID 0000-0002-1006-277X

Funding

The Tertiary Education Trust Fund (TETFUND) of Nigeria TETFund/DR&D/CE/NRF/STI/44/VOL1
6 · The paper itself

Abstract

Irregular use of antibiotics is widespread in Nigeria, which has been reported to be associated with the prevalence of antibiotic resistance. As antibiotics have been reported to be associated with declining male infertility in animal models, we investigated the association between exposure to antibiotics and sperm quality. The study was a prospective case-control study involving 136 infertile men and 154 fertile men recruited from five hospitals in southern Nigeria. Semen analysis was carried out, while Liquid Chromatography Mass Spectrometry was used to assay for various antibiotics in urinary samples. Three antibiotics showed an independent association with sperm quality in the regression analysis. Urinary ampicillin was associated with more than a 3 mL decline in sperm count in the cases, with no significant effects shown in the control group. Similarly, a significant association of urinary chloramphenicol with sperm motility and sperm morphology was shown in cases of infertility. In contrast, an independent association of urinary tetracycline with increased sperm motility in men with infertility was found, but no significant association was shown in fertile men. We conclude that urinary antibiotics-ampicillin, tetracycline, and chloramphenicol-may be associated with varying sperm characteristics and sperm quality in Nigerian men.

Indexed as

case–control studymale infertilityNigeriasperm qualityurinary antibiotics

Identifiers

PMID41149758
PMCPMC12565119

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