Evidence map›Paper›PMID 41149704›Full record

ArticleJournal of functional biomaterials2025

Development of Bioceramic Bone-Inspired Scaffolds Through Single-Step Melt-Extrusion 3D Printing for Segmental Defect Treatment.

Aikaterini Dedeloudi, Pietro Maria Bertelli, Laura Martinez-Marcos, Thomas Quinten, Imre Lengyel, Sune K Andersen, Dimitrios A Lamprou

Abstract read
In one paragraph

Article in Journal of functional biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aikaterini DedeloudiSchool of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.ORCID 0000-0003-3905-8894
Pietro Maria BertelliWellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.ORCID 0009-0006-2439-697X
Laura Martinez-MarcosJohnson & Johnson Innovative Medicine, Oral Solids Development, Research & Development, Turnhoutseweg 30, 2340 Beerse, Belgium.
Thomas QuintenJohnson & Johnson Innovative Medicine, Oral Solids Development, Research & Development, Turnhoutseweg 30, 2340 Beerse, Belgium.
Imre LengyelWellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.ORCID 0000-0001-7467-2174
Sune K AndersenJohnson & Johnson Innovative Medicine, Oral Solids Development, Research & Development, Turnhoutseweg 30, 2340 Beerse, Belgium.ORCID 0000-0002-9721-2821
Dimitrios A LamprouSchool of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.ORCID 0000-0002-8740-1661

Funding

Project 4 - Mechanisms of pyrophosphate dysregulationP01AG081167 · NIA · MEDICAL COLLEGE OF WISCONSIN · PI Francesca M Marassi · 2023 to 2026
$13.0M
NIA NIH HHS P01 AG081167NIH HHS 1P01AG081167-01The study was supported by Johnson & Johnson Innovative Medicine, by the Engineering and Physical Sciences Research Council [grant number EP/T518074/1] EP/T518074/1
6 · The paper itself

Abstract

The increasing demand for novel tissue engineering (TE) applications in bone tissue regeneration underscores the importance of exploring advanced manufacturing techniques and biomaterials for personalised treatment approaches. Three-dimensional printing (3DP) technology facilitates the development of implantable devices with intricate geometries, enabling patient-specific therapeutic solutions. Although Fused Filament Fabrication (FFF) and Direct Ink Writing (DIW) are widely utilised for fabricating bone-like implants, the need for multiple processing steps often prolongs the overall production time. In this study, a single-step melt-extrusion 3DP technique was performed to develop multi-material scaffolds including bioceramics, hydroxyapatite (HA), and

Indexed as

3D printingbioceramicsbiocompatibilityimplantable scaffoldspolycaprolactone

Identifiers

PMID41149704
PMCPMC12565026

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.