Evidence map›Paper›PMID 41149700›Full record

ArticlePediatric reports2025

Sociodemographic Factors, Intent-Uptake Disparities, and Nirsevimab Availability in Infant RSV Immunoprophylaxis.

Brody J Lipsett, Benjamin N Fogel, Katherine E Shedlock, Ian M Paul, Eric W Schaefer, Ruth E Gardner, Leah D Kaye, Steven D Hicks

Abstract read
In one paragraph

Article in Pediatric reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Brody J LipsettPediatrics, Penn State College of Medicine, 500 University Dr, Hershey, PA 17033, USA.ORCID 0009-0005-5978-5345
Benjamin N FogelPediatrics, Penn State College of Medicine, 500 University Dr, Hershey, PA 17033, USA.ORCID 0000-0001-5388-1241
Katherine E ShedlockPediatrics, Penn State College of Medicine, 500 University Dr, Hershey, PA 17033, USA.ORCID 0000-0002-0306-6828
Ian M PaulPediatrics, Penn State College of Medicine, 500 University Dr, Hershey, PA 17033, USA.ORCID 0000-0002-6344-8609
Eric W SchaeferPublic Health Sciences, Penn State College of Medicine, 700 Crescent Rd, Hershey, PA 17033, USA.
Ruth E GardnerPediatrics, Penn State College of Medicine, 500 University Dr, Hershey, PA 17033, USA.ORCID 0009-0005-0020-944X
Leah D KayePediatrics, Penn State College of Medicine, 500 University Dr, Hershey, PA 17033, USA.
Steven D HicksPediatrics, Penn State College of Medicine, 500 University Dr, Hershey, PA 17033, USA.ORCID 0000-0002-9579-6798

Funding

Ashley Nicole Shellenberger SIDS Research Fund at The Penn State College of Medicine N/A
6 · The paper itself

Abstract

BACKGROUND/

objectivesRespiratory syncytial virus (RSV) is the most common cause of bronchiolitis and infant hospitalization in the US. RSV prevention evolved in 2023 as nirsevimab and maternal RSV pre-fusion vaccine became available for healthy newborns and infants. This study investigates sociodemographic characteristics associated with RSV immunoprophylaxis.

methodsA cross-sectional survey was conducted from November 2023 through March 2024 among a convenience sample of parents of infants aged <8 months who received newborn care or pediatric ambulatory care at a single academic institution in Central Pennsylvania, USA. Logistic regression examined sociodemographic factors associated with RSV immunoprophylaxis uptake. Given the nirsevimab shortage during the 2023-2024 RSV season, a sensitivity analysis was completed for intended immunoprophylaxis.

resultsAmong 118 participants, 66.9% received RSV immunoprophylaxis while 74.5% intended to receive nirsevimab. Higher income, private insurance, out-of-home childcare, and an adult/partner working in healthcare were associated with intended nirsevimab receipt. Participation in the Women, Infants and Children program was associated with lower rates of intended nirsevimab receipt. Out-of-home childcare was associated with both RSV immunoprophylaxis uptake and intended nirsevimab receipt.

conclusionsSociodemographic factors significantly influence the intent to receive nirsevimab and RSV immunoprophylaxis uptake. Having an adult/partner in healthcare was the most significant predictor for intent, suggesting that greater health literacy drives immunization intention. Enrollment in out-of-home childcare was the sole predictor of RSV immunoprophylaxis uptake. These findings highlight the importance of policy initiatives that promote equitable access to RSV immunoprophylaxis, including strategies to address socioeconomic barriers, improve health literacy, and ensure consistent availability of preventive agents for all infants.

Indexed as

health disparitiesimmunizationinfant healthnirsevimabrespiratory syncytial virussocioeconomic status

Identifiers

PMID41149700
PMCPMC12566779

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.