ArticleMetabolites2025
Research on the Changing Characteristics of Milk Composition and Serum Metabolites Across Various Lactation Periods in Xinggao Sheep.
Article in Metabolites, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Effects of Prepartum Supplementation with Flaxseed and Black Soldier Fly Larvae Oils on Fatty Acid Composition and Lipid Quality Indices in Sheep Milk.Molecules (Basel, Switzerland) · 2026Article
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9 authors.
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Abstract
backgroundThe variation in sheep milk composition is closely related to the sheep's metabolic status. This study aimed to analyze the milk composition and serum metabolic characteristics of Xinggao sheep during different lactation periods and to evaluate the association between milk quality traits and body metabolism.
methodsEighteen intensively reared ewes were divided into three groups: an early lactation group (MA), a mid-lactation group (MB), and a late lactation group (MC). Milk components were detected by infrared spectroscopy, and the ewes' serum metabolomic characteristics were detected by liquid chromatography-mass spectrometry (LC-MS). K-means correlation analysis revealed that the milk fat percentage was positively correlated with L-aspartic acid and negatively correlated with citrulline levels. Random forest analysis for metabolite importance ranking showed that methionine sulfoxide and methionine exhibited high mean decrease accuracy and mean decrease Gini index values.
resultsThe milk composition results showed that, compared with MA, the milk fat content and total solids in MB and MC were significantly higher, while the freezing point in the MC was significantly lower. Metabolomic studies showed that 207, 210, and 238 differential metabolites were identified in the comparisons of MA vs. MB MA vs. MC, and MB vs. MC, respectively, and these metabolites were mainly enriched in the pyrimidine metabolism, arachidonic acid metabolism, and arginine biosynthesis pathways. Evaluation of metabolite importance using random forest models revealed that 27 metabolites, including 2-Arachidonyl glycerol ether, methionine, and methionine sulfoxide, showed a high mean decrease accuracy and mean decrease Gini index. Correlation analysis revealed that milk fat percentage and total solids were positively correlated with 11 metabolites, including citrulline, phenylalanine, and octadecylamine, and negatively correlated with isoproterenol, cortisol, and kynurenic acid. The freezing point was positively correlated with cortisol, isoproterenol, and kynurenic acid and negatively correlated with aldosterone, dehydroepiandrosterone, and betaine.
conclusionsThis study showed that there were significant differences in the milk composition and metabolites of Xinggao sheep during different lactation periods, highlighting the impact of lactation stage on milk composition and production performance. We recommend developing targeted nutritional strategies based on the specific metabolic profiles of different lactation periods to optimize the feeding management and nutritional regulation of Xinggao sheep.
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