Evidence map›Paper›PMID 41149606›Full record

ReviewMarine drugs2025

Cancer Cell Cytotoxicity of Marinopyrroles, Pyrrolomycins, and Their Derivatives.

Jeffrey M Zimmerly, Nicholas A Armstrong, Clare F Euteneuer, Brianna N Davis, M Beth Griffis-Anchala, Angelique Vargas, Paul H Davis

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Marine drugs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jeffrey M ZimmerlyDepartment of Biology, University of Nebraska at Omaha, Omaha, NE 68182, USA.
Nicholas A ArmstrongDepartment of Biology, University of Nebraska at Omaha, Omaha, NE 68182, USA.
Clare F EuteneuerDepartment of Biology, University of Nebraska at Omaha, Omaha, NE 68182, USA.ORCID 0009-0002-8193-9732
Brianna N DavisDepartment of Biology, University of Nebraska at Omaha, Omaha, NE 68182, USA.ORCID 0009-0002-3230-4378
M Beth Griffis-AnchalaDepartment of Biology, University of Nebraska at Omaha, Omaha, NE 68182, USA.
Angelique VargasDepartment of Biology, University of Nebraska at Omaha, Omaha, NE 68182, USA.ORCID 0009-0004-2558-7992
Paul H DavisDepartment of Biology, University of Nebraska at Omaha, Omaha, NE 68182, USA.ORCID 0000-0002-0526-3841

Funding

UNMC Structural Biology CoreP20GM103427 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Heather Colleen Jensen-Smith · 2012 to 2026
$59.2M
NIGMS NIH HHS P20 GM103427NIH HHS 5P20GM103427-23
6 · The paper itself

Abstract

Marine-derived secondary metabolites have emerged as a rich potential source of anticancer agents, with marinopyrroles and pyrrolomycins representing structurally distinct halogenated pyrroles of interest. Initially characterized for their potent antibacterial properties, these compounds were later shown to exert cytotoxic activity across diverse hematologic and solid malignancies, frequently correlating with Mcl-1 dependence. Marinopyrrole A, a marine-derived natural product, exemplified this potential by inducing proteasomal degradation of Mcl-1, thereby sensitizing resistant cancer cells to Bcl-2 inhibitors and TRAIL-based therapies. In parallel, pyrrolomycins, particularly pyrrolomycin C and members of the F-series, demonstrated potent activity with submicromolar IC

Indexed as

Antineoplastic AgentsNeoplasmsPyrrolesAnimalsAquatic OrganismsCell Line, TumorHumansAntineoplastic Agentsmarinopyrrole APyrrolesanticancermarine-derived compoundsmarinopyrrolepyrrolomycin

Identifiers

PMID41149606
PMCPMC12565171

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.