ArticleNanomaterials (Basel, Switzerland)2025
Hair-Template Confinement Assembly of Nanomaterials Enables a Robust Single-Hair Surface-Enhanced Raman Spectrocopy Platform for Trace Analysis.
Article in Nanomaterials (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Surface-enhanced Raman spectroscopy (SERS) enables ultra-sensitive molecular detection and has broad analytical and biomedical applications; recent advances focus on high-performance substrates and innovative detection strategies. However, achieving controllable and reproducible substrate fabrication-particularly using natural templates such as hair-remains challenging, limiting SERS application in trace analysis and on-site detection. This study developed a single-hair in situ SERS platform using a natural hair template. Confinement within hair cuticle grooves and capillary-evaporation assembly enables dense arrangement of cetyltrimethylammonium bromide-coated Au nanorods and polyvinylpyrrolidone-coated Au nanoparticles, forming uniform plasmonic nanoarrays. Spectroscopy and microscopy analyses confirmed the regular alignment of nanostructures along the hair axis with denser packing at the edges. The platform detected crystal violet at 10
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