Evidence map›Paper›PMID 41149445›Full record

ArticleGels (Basel, Switzerland)2025

Investigation of Rheological Characteristics of Thermosensitive Nasal In Situ Gels Based on P407 and Their Effect on Spray Pattern.

Natalia Menshutina, Vladislav Derkach, Elizaveta Mokhova, Mariia Gordienko

Abstract read
In one paragraph

Article in Gels (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Natalia MenshutinaThe Department of Chemical and Pharmaceutical Engineering, Mendeleev University of Chemical Technology of Russia (MUCTR), Moscow 125047, Russia.ORCID 0000-0001-7806-1426
Vladislav DerkachThe Department of Chemical and Pharmaceutical Engineering, Mendeleev University of Chemical Technology of Russia (MUCTR), Moscow 125047, Russia.ORCID 0009-0007-3508-2586
Elizaveta MokhovaThe Department of Chemical and Pharmaceutical Engineering, Mendeleev University of Chemical Technology of Russia (MUCTR), Moscow 125047, Russia.ORCID 0000-0002-9995-6752
Mariia GordienkoThe Department of Chemical and Pharmaceutical Engineering, Mendeleev University of Chemical Technology of Russia (MUCTR), Moscow 125047, Russia.ORCID 0000-0002-8485-9861

Funding

Ministry of Science and Higher Education of the Russian Federation FSSM-2025-0003
6 · The paper itself

Abstract

This article presents the results of a study on the rheological characteristics of in situ thermosensitive nasal gels based on poloxamer 407 (P407) and their effect on spray angle. The development of new drug delivery systems based on in situ thermosensitive gels can overcome several shortcomings of traditional nasal sprays associated with mucociliary clearance and low mucoadhesion. Using the cold method, samples based on P407 were prepared in pure form, in combination with poloxamer 188 (P188), and with the addition of several mucoadhesive polymers: chitosan, sodium alginate, and hydroxypropyl methylcellulose (HPMC). Analytical studies were carried out for all obtained samples, which showed that the gelling temperature (T

Indexed as

in situ gelsmathematical modelingmucoadhesive polymersnasal deliverypoloxamerrheologysprayspray pattern

Identifiers

PMID41149445
PMCPMC12564714

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.