Evidence map›Paper›PMID 41149417›Full record

ArticleGels (Basel, Switzerland)2025

Preparation and Characterization of an Acid-Responsive ZIF-8 Hydrogel Dressing with Sustained-Release Function for Targeted Therapy of Periodontitis.

Bingbing Chen, Mengqi Hao, Hao Cui, Rui Zeng, Hang Ma, Anying Long, Xuegang Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gels (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bingbing ChenEngineering Research Center of Coptis Development and Utilization, Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
Mengqi HaoEngineering Research Center of Coptis Development and Utilization, Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
Hao CuiSichuan Provincial Engineering Research Center of Agricultural and Forestry Waste Resource Utilization, Chengdu Normal University, Chengdu 611130, China.
Rui ZengSichuan Provincial Engineering Research Center of Agricultural and Forestry Waste Resource Utilization, Chengdu Normal University, Chengdu 611130, China.
Hang MaEngineering Research Center of Coptis Development and Utilization, Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
Anying LongCollege of Chemical Engineering, Guizhou University of Engineering Science, Bijie 551700, China.
Xuegang LiEngineering Research Center of Coptis Development and Utilization, Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.

Funding

Special Fund for Youth Team of Southwest University SWU-XJLJ202306the National Nature Science Foundation of China 42177012the National Nature Science Foundation of Chongqing CSTB2022NSCQ-MSX1453the Open Fund Project of Hubei Key Laboratory of Mine Environmental Pollution Control&Remediation 2024KTJ10
6 · The paper itself

Abstract

Periodontitis is a chronic oral inflammatory disease whose treatment is often hindered by poor drug retention, prolonged therapeutic regimens, and the rise of antibiotic resistance. In this study, we developed a Hydrogel@ZIF-8@metronidazole (Hydrogel@ZIF-8@MNZ) nanocomposite dressing for targeted, sustained, and in situ antimicrobial therapy. This system integrates ZIF-8, a pH-responsive metal-organic framework, with the antimicrobial agent metronidazole (MNZ), encapsulated within a crosslinked hydrogel matrix to enhance stability and retention in the oral environment. Drug release studies demonstrated that MNZ release was significantly accelerated under acidic conditions (pH 5.0), mimicking the periodontal microenvironment. The Hydrogel@ZIF-8 composite achieved a maximum MNZ adsorption capacity of 132.45 mg·g

Indexed as

drug carrierFusobacterium nucleatumHydrogel@ZIF-8@MNZperiodontitispH-responsive

Identifiers

PMID41149417
PMCPMC12563438

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.