Laser-Based Fabrication of Hydrogel Scaffolds for Medicine: From Principles to Clinical Applications.

Hydrogel scaffolds have emerged as pivotal materials in regenerative medicine due to their biocompatibility, tunable mechanical properties, and ability to mimic the extracellular matrix. However, conventional fabrication techniques often lack the precision required to create complex architectures, limiting their effectiveness in tissue engineering. This review explores advanced laser-based fabrication methods, such as two-photon polymerization, laser-induced forward transfer, selective laser sintering/melting, and laser direct writing, which offer unparalleled resolution and control over scaffold geometry. These techniques enable the production of intricate 3D structures tailored to specific clinical needs, from vascular networks to patient-specific implants. We analyze the principles, advantages, and limitations of each method, highlighting their biomedical applications and the challenges of scalability, material compatibility, and cost. By bridging the gap between laboratory research and clinical implementation, laser-based technologies hold significant promise for advancing personalized medicine and tissue regeneration.