Transparent Elastic Wound Dressing Gel Supporting Drug Release: Synergistic Effects of Poly(Vinyl Alcohol)/Chitosan Hybrid Matrix.

Lifei Chen, Ningning Yuan, Zhenjiang Tan, Jianwei Zhang, Lishi Zhang, Wenwei Tang, Cheng Chen, Donghai Lin

Abstract read

In one paragraph

Article in Gels (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Lifei ChenShanghai Key Laboratory of Engineering Materials Application and Evaluation, School of Energy and Materials, Shanghai Polytechnic University, Shanghai 201209, China.

Ningning YuanShanghai Key Laboratory of Engineering Materials Application and Evaluation, School of Energy and Materials, Shanghai Polytechnic University, Shanghai 201209, China.

Zhenjiang TanShanghai Key Laboratory of Engineering Materials Application and Evaluation, School of Energy and Materials, Shanghai Polytechnic University, Shanghai 201209, China.ORCID 0009-0002-4101-003X

Jianwei ZhangShanghai Key Laboratory of Engineering Materials Application and Evaluation, School of Energy and Materials, Shanghai Polytechnic University, Shanghai 201209, China.ORCID 0009-0003-0688-285X

Lishi ZhangSchool of Resources and Environmental Engineering, Shanghai Polytechnic University, Shanghai 201209, China.

Wenwei TangSchool of Mathematics Physics and Statistics, Shanghai Polytechnic University, Shanghai 201209, China.

Cheng ChenShanghai Key Laboratory of Engineering Materials Application and Evaluation, School of Energy and Materials, Shanghai Polytechnic University, Shanghai 201209, China.ORCID 0000-0002-9813-532X

Donghai LinShanghai Key Laboratory of Engineering Materials Application and Evaluation, School of Energy and Materials, Shanghai Polytechnic University, Shanghai 201209, China.ORCID 0000-0003-4073-4132

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wound infection is one of the most critical factors affecting the healing process. Therefore, the development of wound dressings with excellent antibacterial effects has become a research hotspot in the current academic field. We prepared AgNPs (silver nanoparticles) via a redox method, combined them with Poly(vinyl alcohol)/chitosan (PVA/CS), and dried the mixture into a film to fabricate a silver-loaded hydrogel film dressing with excellent antibacterial properties. Uniaxial tensile tests on the samples revealed that the prepared film dressings exhibited good mechanical properties, preventing fracture caused by external forces. Protein adsorption experiments indicated their favorable protein adsorption performance, which can adsorb microorganisms on the external surface of the dressing. By leveraging the bactericidal mechanism of AgNPs, the dressing achieves efficient antibacterial effects. Additionally, the dressing prepared by this method features good transparency, facilitating routine observation of the wound area without removing the dressing and maintaining a sterile environment for an extended period. Finally, we verified the drug loading and drug release capabilities of the dressing, and found that it has good drug loading capacity and drug release effect. This preliminarily proves its effectiveness and provides more possibilities for subsequent research on composite drugs. This study provides new insights for exploring the clinical application of multifunctional silver-loaded wound dressings.

Indexed as

antimicrobialdressingnanosilverwound healing

Identifiers

PMID41149376

DOI10.3390/gels11100771

PMCPMC12562730

What OpenQuestion holds

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LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.