ArticleGels (Basel, Switzerland)2025
Biofunctional Carboxymethyl Chitosan Hydrogel Incorporating Hyaluronic Acid and RGD Peptides for Accelerated Wound Repair.
Article in Gels (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Biomedical Hydrogels Based on Oxidized Hyaluronic Acid and Carboxymethyl Chitosan Coordinated with Magnesium Ions.Biomimetics (Basel, Switzerland) · 2026Article
- An Alkaloid from MarinePharmaceuticals (Basel, Switzerland) · 2026Article
- Robust Polyurethane Hydrogels Based on Dynamic Disulfide Bonds and Pendant Tertiary Amines with Room-Temperature Self-Healing and pH Responsiveness.Gels (Basel, Switzerland) · 2026Article
- Recent Advances and Applications of Chitin and Chitosan Hydrogel Scaffolds in Tissue Engineering.Gels (Basel, Switzerland) · 2026Review
- Biocompatible Photocrosslinked Chitosan- and Gelatin-Based Hydrogels for Wound Healing Applications.Gels (Basel, Switzerland) · 2026Article
- Dual-Crosslinked Gelatin/Dextran Medical Hydrogels Based on Aldimine Condensation and Photopolymerization.Gels (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Carboxymethyl chitosan (CMC)-based hydrogels have emerged as promising candidates for wound dressing applications due to their excellent biocompatibility and tunable physicochemical properties. In this study, a novel hydrogel functionalized with hyaluronic acid (HA) and RGD peptides (RGD) was fabricated and evaluated for its structural characteristics and wound-healing potential. Using CMC as the base matrix and EDC/NHS as crosslinking agents, four hydrogel variants were fabricated: CMC gel, CMC-HA gel, CMC-RGD gel, and CMC-HA-RGD gel. The preliminary cell compatibility experiment identified the optimal formulation as 1% CMC, 0.9% HA, and 0.02 mg/mL RGD, crosslinked with 1 vol% EDC and 0.05 wt% NHS. Scanning electron microscopy showed a porous architecture (100-400 μm), conducive to fibroblast viability and proliferation. Zeta potential measurements (|ζ| > 30 mV) indicated colloidal stability of the hydrogel system. Fourier-transform infrared spectroscopy confirmed successful crosslinking and integration of HA and RGD via hydrogen bonding and electrostatic interactions, forming a stable three-dimensional network. Thermogravimetric analysis revealed enhanced thermal stability upon HA/RGD incorporation. CCK-8 assays demonstrated significantly improved cell viability with HA/RGD loading (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.