Evidence map›Paper›PMID 41149348›Full record

ReviewBiosensors2025

Single-Molecule Detection Technologies: Advances in Devices, Transduction Mechanisms, and Functional Materials for Real-World Biomedical and Environmental Applications.

Sampa Manoranjan Barman, Arpita Parakh, A Anny Leema, P Balakrishnan, Ankita Avthankar, Dhiraj P Tulaskar, Purshottam J Assudani, Shon Nemane, Prakash Rewatkar, Madhusudan B Kulkarni and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biosensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sampa Manoranjan BarmanDepartment of Electronics and Communication Engineering, Tulsiramji Gaikwad-Patil College of Engineering and Technology, Nagpur 441108, India.
Arpita ParakhSchool of Electrical and Electronics Engineering, Ramdeobaba University, Nagpur 440013, India.ORCID 0000-0003-0082-2162
A Anny LeemaSchool of Computer Science and Engineering, Vellore Institute of Technology, Vellore 632014, India.
P BalakrishnanSchool of Computer Science and Engineering, Vellore Institute of Technology, Vellore 632014, India.
Ankita AvthankarDepartment of Computer Science and Engineering, Symbiosis Institute of Technology, Nagpur Campus, Symbiosis International (Deemed University), Pune 440035, India.ORCID 0009-0001-3354-1802
Dhiraj P TulaskarDepartment of Electronics & Telecommunication Engineering, Shri Sant Gajanan Maharaj College of Engineering, Shegaon 444203, India.ORCID 0000-0001-6540-2471
Purshottam J AssudaniSchool of Computer Science and Engineering, Ramdeobaba University, Nagpur 440013, India.
Shon NemaneDepartment of Electronics & Telecommunication Engineering, Shri Sant Gajanan Maharaj College of Engineering, Shegaon 444203, India.
Prakash RewatkarDepartment of Mechanical Engineering, Israel Institute of Technology, Haifa 3200003, Israel.ORCID 0000-0003-1076-0698
Madhusudan B KulkarniDepartment of Electronics and Communication Engineering, Manipal Institute of Technology, Manipal Academy of Higher Education (MAHE), Manipal 576104, India.ORCID 0000-0002-2911-3784
Manish BhaiyyaDepartment of Chemical Engineering and the Russell Berrie Nanotechnology Institute, Technion Israel Institute of Technology, Haifa 3200003, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Single-molecule detection (SMD) has reformed analytical science by enabling the direct observation of individual molecular events, thus overcoming the limitations of ensemble-averaged measurements. This review presents a comprehensive analysis of the principles, devices, and emerging materials that have shaped the current landscape of SMD. We explore a wide range of sensing mechanisms, including surface plasmon resonance, mechanochemical transduction, transistor-based sensing, optical microfiber platforms, fluorescence-based techniques, Raman scattering, and recognition tunneling, which offer distinct advantages in terms of label-free operation, ultrasensitivity, and real-time responsiveness. Each technique is critically examined through representative case studies, revealing how innovations in device architecture and signal amplification strategies have collectively pushed the detection limits into the femtomolar to attomolar range. Beyond the sensing principles, this review highlights the transformative role of advanced nanomaterials such as graphene, carbon nanotubes, quantum dots, MnO

Indexed as

Biosensing TechniquesSingle Molecule ImagingHumansNanostructuresSpectrum Analysis, RamanSurface Plasmon Resonancebiosensingdiagnosticsenvironmental and clinical sensingfluorescence-based detectionlabel-free detectionnanomaterialsoptical microfiberspoint-of-care diagnosticsRaman scatteringrecognition tunnelingsensingsingle-molecule detection (SMD)surface plasmon resonance (SPR)transistor-based biosensors

Identifiers

PMID41149348
PMCPMC12564833

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.