Evidence map›Paper›PMID 41149270›Full record

ArticleJournal of cardiovascular development and disease2025

The Association Between Short-Term Blood Pressure Variability and Inflammation in Healthy Young Adults.

Charles J Weeks, Bayu B Bekele, Michelle Altvater, Jie Cheng, Haidong Zhu, Ying Huang, Deborah A Jehu, Abigayle B Simon, Wenjun Li, Yanbin Dong

Abstract read
In one paragraph

Article in Journal of cardiovascular development and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Charles J WeeksMedical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0009-0007-8082-3320
Bayu B BekeleGeorgia Prevention Institute, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0001-8590-4874
Michelle AltvaterGeorgia Prevention Institute, Augusta University, Augusta, GA 30912, USA.
Jie ChengDepartment of Public Health, Center for Health Statistics and Biostatistics Core, University of Massachusetts-Lowell, Lowell, MA 01854, USA.
Haidong ZhuGeorgia Prevention Institute, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-8384-0464
Ying HuangGeorgia Prevention Institute, Augusta University, Augusta, GA 30912, USA.
Deborah A JehuDepartment of Community & Behavioral Health Sciences, School of Public Health, Augusta University, Augusta, GA 30904, USA.ORCID 0000-0002-9084-7445
Abigayle B SimonMedical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-7394-2088
Wenjun LiGeorgia Prevention Institute, Augusta University, Augusta, GA 30912, USA.
Yanbin DongGeorgia Prevention Institute, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0001-7848-7160

Funding

Early Life Stress, Damage Associated Molecular Patterns, and Cardiovascular RiskR01HL136630 · NHLBI · AUGUSTA UNIVERSITY · PI DONG, YANBIN · 2018 to 2020
$2.3M
NHLBI NIH HHS R01 HL136630NHLBI NIH HHS R01HL136630
6 · The paper itself

Abstract

Blood pressure variability (BPV) is linked to cardiovascular disease (CVD) and systemic inflammation in adults, but its relevance in young, healthy populations remains unclear. This study examined the association between short-term BPV and inflammatory markers in 447 normotensive participants (mean age, 22.9 years) from the Georgia Stress and Heart (GSH) study, a cohort of Non-Hispanic Black and White individuals. Participants underwent 24 h ambulatory blood pressure monitoring and assessment of serum inflammatory markers, including hs-CRP, IFN-γ, IL-6, and TNF-α. BPV was quantified using average real variability (ARV), and generalized estimating equations (GEEs) were used to evaluate associations, adjusting for age, sex, race, and mean blood pressure. Diastolic BPV was significantly, positively associated with hs-CRP and TNF-α, whereas systolic BPV was not associated with any inflammatory marker. Specifically, 24 h diastolic BPV was positively associated with hs-CRP (

Indexed as

ambulatory blood pressure monitoringblood pressure variabilitycardiovascular diseasesC-reactive proteincytokinesdiastolic blood pressureinflammationtumor necrosis factor alphayoung adult

Identifiers

PMID41149270
PMCPMC12564484

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.