Evidence map›Paper›PMID 41148837›Full record

ArticleCells2025

Protective Immune Signatures Associated with Latent TB Infection in PLHIV-Insights from an Integrative Prospective Immune Monitoring Study.

Shilpa Bhowmick, Pratik Devadiga, Sapna Yadav, Nandan Mohite, Pranay Gurav, Tejaswini Pandey, Varsha Padwal, Namrata Neman, Aarya Suryawanshi, Satyajit Musale and 17 more

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Shilpa BhowmickViral Immunopathogenesis Lab, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai 400012, India.
Pratik DevadigaDepartment of Molecular Immunology and Microbiology, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai 400012, India.
Sapna YadavViral Immunopathogenesis Lab, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai 400012, India.
Nandan MohiteViral Immunopathogenesis Lab, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai 400012, India.
Pranay GuravViral Immunopathogenesis Lab, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai 400012, India.ORCID 0000-0003-0475-446X
Tejaswini PandeyViral Immunopathogenesis Lab, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai 400012, India.
Varsha PadwalViral Immunopathogenesis Lab, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai 400012, India.
Namrata NemanViral Immunopathogenesis Lab, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai 400012, India.
Aarya SuryawanshiViral Immunopathogenesis Lab, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai 400012, India.
Satyajit MusaleViral Immunopathogenesis Lab, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai 400012, India.
Amit Kumar SinghViral Immunopathogenesis Lab, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai 400012, India.ORCID 0000-0002-1089-121X
Sharad BhagatViral Immunopathogenesis Lab, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai 400012, India.
Snehal KaginkarViral Immunopathogenesis Lab, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai 400012, India.
Harsha PalavViral Immunopathogenesis Lab, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai 400012, India.ORCID 0000-0001-7542-0761
Shantanu BirjeDepartment of Child Health research, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai 400012, India.ORCID 0009-0004-0872-1088
Shilpa KerkarDepartment of Child Health research, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai 400012, India.
Susan Idicula-ThomasBiomedical Informatics Centre, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai 400012, India.
Vidya NagarDepartment of Medicine, Grant Medical College and JJ Group of Hospitals, Mumbai 400008, India.
Priya PatilDepartment of Medicine, Grant Medical College and JJ Group of Hospitals, Mumbai 400008, India.
Sachee AgrawalDepartment of Microbiology, TN Medical College and BYL Nair Hospital, Mumbai 400008, India.
Sushma GaikwadDepartment of Medicine, TN Medical College and BYL Nair Hospital, Mumbai 400008, India.
Jayanthi ShastriDepartment of Microbiology, TN Medical College and BYL Nair Hospital, Mumbai 400008, India.
Nupur MukherjeeDepartment of Cell Physiology and Pathology, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai 400008, India.
Kiran MunneDepartment of Child Health research, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai 400012, India.
Vikrant M BhorDepartment of Molecular Immunology and Microbiology, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai 400012, India.ORCID 0000-0001-9897-4505
Taruna MadanDepartment of Innate Immunity, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai 400012, India.ORCID 0000-0003-2826-2443
Vainav PatelViral Immunopathogenesis Lab, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai 400012, India.

Funding

DBT-Welcome Trust India Alliance IA/TSG/19/600019Indo-US (ICMR-NIH) HIV/INDO-US/162/7/2018-ECD-II
6 · The paper itself

Abstract

Understanding how HIV-1 pathogenesis affects systemic and TB specific immunity in the setting of latent (LTBI+) compared to active TB infection could provide actionable insights for the prevention of reactivation. Fifty HIV-seronegative and 112 HIV-1-positive anti-retroviral therapy (ART)-naïve participants were stratified as LTBI+ (

Indexed as

HIV InfectionsLatent TuberculosisAdultCD4-Positive T-LymphocytesCoinfectionFemaleHIV-1HumansIsoniazidMaleMiddle AgedMonitoring, ImmunologicProspective StudiesIsoniazidcytokinesDosR/Rpfflow cytometryHIV pathogenesisHIV-TB coinfectionintracellular cytokine staining assayLTBIPD-1 expressionregulatory T cellsT-cell activation

Identifiers

PMID41148837
PMCPMC12562479

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.