Evidence map›Paper›PMID 41148817›Full record

ArticleCells2025

IL-6 Blockade Enhances the Efficacy of CDK4/6 Inhibitor in

Li Pan, Changyou Shi, Joungil Choi, Jiayuh Lin

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. RareOncology letters · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Li PanDepartment of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Changyou ShiDepartment of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Joungil ChoiFlow Cytometry Core Service, VA Maryland Healthcare System, 10N. Greene St., Baltimore, MD 21201, USA.
Jiayuh LinDepartment of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0002-5618-8781

Funding

BLRD VA I01 BX005788VA Biomedical Laboratory Research & Development 1I01BX005788-01
6 · The paper itself

Abstract

Breast cancer gene 1 (

Indexed as

BRCA1 ProteinCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6Interleukin-6Interleukin-6 InhibitorsMutationProtein Kinase InhibitorsTriple Negative Breast NeoplasmsAminopyridinesAnimalsApoptosisBenzimidazolesCell Line, TumorCell MovementCell ProliferationFemaleabemaciclibAminopyridinesBenzimidazolesBRCA1 ProteinBRCA1 protein, humanCDK4 protein, humanCDK6 protein, humanCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6Interleukin-6Interleukin-6 InhibitorsProtein Kinase InhibitorsabemaciclibbazedoxifeneBRCA1 mutationCDK4/6IL-6 inhibitorIL-6/STAT3 signalingtriple-negative breast cancer (TNBC)

Identifiers

PMID41148817
PMCPMC12564161

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.