Evidence map›Paper›PMID 41148629›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2025

Evaluation of Genetic Polymorphisms of HOTTIP (rs5883064, rs1859168, rs2067087) in Patients with Non-Hodgkin Lymphoma and Comparison with Healthy Subjects.

Masoomeh Sadraei, Seyed Mehdi Hashemi, Hossein Mozaffari, Mohsen Taheri, Reza Mahdizadeh, Gholamreza Bahari

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Masoomeh SadraeiDepartment of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Seyed Mehdi HashemiClinical Immunology Research Center, Department of Internal Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.ORCID 0000-0003-4948-9639
Hossein MozaffariDepartment of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Mohsen TaheriGenetics of Non- Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
Reza MahdizadehDepartment of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Gholamreza BahariDepartment of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.ORCID 0000-0003-2531-4236

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNon-Hodgkin Lymphoma (NHL) is a group of blood cancers in which lymphoid cells develop abnormal growth due to genetic changes or other factors without Reed-Sternberg cells. Given the proven role of HOTTIP gene polymorphisms in the prognosis, diagnosis, and treatment of different kinds of carcinomas, this study investigated the association between rs5883064, rs1859168, and rs2067087 polymorphisms of the gene with NHL susceptibility in a population of Zahedan. MATERIALS AND

methodsA total of 190 NHL cases (122 males and 68 females), aged 44.45±15.29 years, and 190 healthy individuals (107 males and 83 females, 43.13±12.15 years) were collected as study subjects. The gene polymorphisms were examined by PCR RFLP and ARMS methods.

resultsOur results showed that the rs5883064 Del>Ins polymorphism of the HOTTIP gene has a protective role and significantly reduces the risk of lymphoma. The 1859168 C>A variant in the co-dominant model is a risk criterion for non-Hodgkin lymphoma and significantly increases this disease's risk. The HOTTIP rs2067087 G>C variant had a protective role and significantly reduced the risk of lymphoma.

conclusionOur results showed that the association between HOTTIP gene polymorphisms and NHL incidence has a significant pattern. More studies in larger populations and various ethnicities are recommended to confirm our findings.

Indexed as

Biomarkers, TumorGenetic Predisposition to DiseaseLymphoma, Non-HodgkinPolymorphism, Single NucleotideRNA, Long NoncodingAdultCase-Control StudiesFemaleFollow-Up StudiesGenotypeHumansMaleMiddle AgedPrognosisBiomarkers, Tumorlong noncoding RNA HOTTIP, humanRNA, Long NoncodingHOTTIPNon-Hodgkin lymphomaPolymorphism

Identifiers

PMID41148629
PMCPMC12906782

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