ArticleEJNMMI radiopharmacy and chemistry2025
Automated radiosynthesis of [
Article in EJNMMI radiopharmacy and chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Pathogen-Specific PET Imaging of Pulmonary Infection Using [Chemical & biomedical imaging · 2026Article
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7 authors.
Funding
Abstract
backgroundInfections pose a significant risk to immunocompromised individuals, and accurate, efficient diagnosis remain challenging. Current imaging methods like MRI and FDG PET lack pathogen specificity which complicate diagnosis and lead to overuse of antibiotics. Recent data shows that [
resultsThis study optimized and automated the radiosynthesis of [¹⁸F]fluoromannitol ([¹⁸F]FMtl) on a Trasis AllinOne synthesizer. The 105-minute synthesis achieved an average yield of 11.0% (n = 19) with > 97% radiochemical purity, and the product remained stable for at least 8 h. While yield was lower than the previously reported manual method, automation enabled reproducibility and sterility. Process improvements included optimizing evaporation steps and reaction temperature, which significantly increased fluorine incorporation and yield. The process was validated to meet USP < 823 > regulatory requirements including full QC testing on three consecutive batches.
conclusionsAn automated method for the radiochemical synthesis of [
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.