Evidence map›Paper›PMID 41148480›Full record

ReviewInternational journal of clinical oncology2025

The role of hypoxia-inducible factor-1α on colon cancer progression and metastasis.

Mohamed J Saadh, Mareb Hamed Ahmed, Rafid Jihad Albadr, Gaurav Sanghvi, R Roopashree, Aditya Kashyap, A Sabarivani, Jasur Rizaev, Waam Mohammed Taher, Mariem Alwan and 2 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in International journal of clinical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mohamed J SaadhFaculty of Pharmacy, Middle East University, Amman, 11831, Jordan.
Mareb Hamed AhmedCollege of Dentistry, Alnoor University, Mosul, Iraq. mareb.hamed@alnoor.edu.iq.
Rafid Jihad AlbadrAhl Al Bayt University, Kerbala, Iraq.
Gaurav SanghviMarwadi University Research Center, Department of Microbiology, Faculty of Science, Marwadi University, Rajkot, 360003, Gujarat, India.
R RoopashreeDepartment of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to Be University), Bangalore, Karnataka, India.
Aditya KashyapCentre for Research Impact & Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, 140401, Punjab, India.
A SabarivaniDepartment of Biomedical, Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu, India.
Jasur RizaevDepartment of Public Health and Healthcare Management, Rector, Samarkand State Medical University, 18, Amir Temur Street, Samarkand, Uzbekistan.
Waam Mohammed TaherCollege of Nursing, National University of Science and Technology, Nasiriyah, Dhi Qar, Iraq.
Mariem AlwanPharmacy College, Al-Farahidi University, Baghdad, Iraq.
Mahmod Jasem JawadDepartment of Pharmacy, Al-Zahrawi University College, Karbala, Iraq.
Ali M Ali Al-NuaimiDepartment of Chemistry, Gilgamesh Ahliya University, Baghdad, Iraq.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite advancements in technology and research in clinical oncology, colon cancer remains a leading cause of cancer-related deaths worldwide. Hypoxic conditions, characterized by diminished oxygen levels in the tumor microenvironment, have been implicated in the tumorigenesis of various types of cancer. HIF-1α, as a principal hypoxic transcription factor, promotes tumor progression by interacting with multiple molecular pathways and oncogenic functions. Various studies have demonstrated that HIF-1α can promote the growth and development of colon tumor cells by stimulating downstream target genes through multiple mechanisms, such as immune evasion, cancer stem cell enrichment, metastasis, invasion, angiogenesis, and glycolysis. In this review, we comprehensively discuss the mechanisms and functions of HIF-1α that contribute to the growth and progression of colon cancer in the hypoxic tumor microenvironment.

Indexed as

Colonic NeoplasmsHypoxia-Inducible Factor 1, alpha SubunitAnimalsDisease ProgressionGene Expression Regulation, NeoplasticHumansNeoplasm MetastasisNeoplastic Stem CellsNeovascularization, PathologicTumor MicroenvironmentHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitCancer therapyColon cancerHIF-1αHypoxiaHypoxia inducible factor-1

Identifiers

PMID41148480

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.