ArticleDiscover oncology2025
Mediation Mendelian randomization study of plasma proteomics reveals the causal relationship and potential mechanisms between iron and colorectal adenocarcinoma.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Colorectal adenocarcinoma (CRA) is the third most frequently detected cancer worldwide. The relationship between iron and CRA is ambiguous and interactive, especially when considering the heterogenesis of colon and rectal adenocarcinoma. This research utilized Mendelian randomization to examine how serum iron levels are linked to colon and rectal adenocarcinoma, respectively. Furthermore, proteomic data-based mediation analysis was followed by enrichment analysis to explore mediating pathways. Analysis using magnetic resonance imaging showed that higher levels of iron in the blood were linked to a higher risk of developing colon and rectal adenocarcinoma. In proteomic mediation analysis, signal transducer and activator of transcription 1 (STAT1) and interleukin-22 receptor subunit alpha-1 (IL-22RA1) show the highest mediating ratios among 32 proteins associated with colon adenocarcinoma. In contrast, neural cell adhesion molecule 1 (NCAM1), torsin-1a-interacting protein 2 (TOR1AIP2), and polymeric immunoglobulin receptor (PIGR) exhibit the highest mediating ratios among 31 proteins linked to rectal adenocarcinoma. The signaling of interferon-alpha/beta and interleukin-6(IL-6) were the most relevant pathways in colon adenocarcinoma. The apoptosis pathways were the main pathways involved in rectal adenocarcinoma. Our research clarifies the causal impact of serum iron levels in the development of CRA, emphasizing unique molecular pathways involved in CRA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.