Evidence map›Paper›PMID 41148430›Full record

ArticleSleep & breathing = Schlaf & Atmung2025

Sleep quality and associated factors in patients with inflammatory bowel disease: a cross-sectional study.

Mehrnaz Asgharnezhad, Saman Maroufizadeh, Adele Isanazar, Zahra Hedayatzadeh, Farahnaz Joukar, Fariborz Mansour-Ghanaei

Abstract read
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In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mehrnaz AsgharnezhadEpidemiology, Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.ORCID 0000-0002-0409-3852
Saman MaroufizadehBiostatistics, Department of Biostatistics and Epidemiology, School of Health, Guilan University of Medical Sciences, Rasht, Iran.ORCID 0000-0001-5794-3876
Adele IsanazarPsychiatry, Kavosh Cognitive Behavior Sciences and Addiction Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.ORCID 0000-0002-3425-2682
Zahra HedayatzadehGenetics, Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.ORCID 0000-0003-2871-2184
Farahnaz JoukarEpidemiology, Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran. farajov@gmail.com.ORCID 0000-0001-8432-8879
Fariborz Mansour-GhanaeiGastroenterology and Hepatology, Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran. fmansourghanaei@gmail.com.ORCID 0000-0002-6264-0025

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeA stable sleep-wake cycle is essential for immune function, and chronic inflammatory conditions like inflammatory bowel disease (IBD) often lead to sleep disturbances and fatigue that may influence disease progression. This study examined the relationship between sleep quality and contributing factors in patients with IBD.

methodsThis cross-sectional study included 307 adult IBD patients (Ulcerative Colitis (UC) and 50 with Crohn's Disease (CD)) enrolled from the Iranian Registry of Crohn's and Colitis (IRCC) between 2022 and 2024 in Guilan, Iran. Data were collected using standardized questionnaires, including the Pittsburgh Sleep Quality Index (PSQI), Generalized Anxiety Disorder-7 (GAD-7), and Patient Health Questionnaire-9 (PHQ-9). Active and inactive IBD were classified using clinical indices and gastroenterologist confirmation. Data were analyzed using univariable and multivariable linear regression.

resultsThe mean age of participants was 45.4 ± 13.1 years, and 67.1% were female. The mean global PSQI score was 3.09, and 11.7% of patients had poor sleep quality. Notable correlations were found between PSQI scores and GAD-7 (r=0.158, P=0.005) and PHQ-9 scores (r=0.246, P<0.001). Multivariable analysis revealed that each one-point increase in PHQ-9 score was associated with a 0.18-point increase in PSQI score (P<0.001), and patients with comorbidities had PSQI scores 1.32 points higher than those without (P=0.043).

conclusionsPoor sleep quality in IBD patients is more strongly associated with depression and comorbidities than with disease activity. These findings highlight the need for routine mental health and comorbidity screening in managing sleep disturbances and call for further research into targeted interventions.

Indexed as

Crohn DiseaseInflammatory Bowel DiseasesSleep QualitySleep Wake DisordersAdultComorbidityCross-Sectional StudiesFemaleHumansIranMaleMiddle AgedSurveys and QuestionnairesAnxiety SymptomsDepression SymptomsGastroenterologyInflammatory Bowel DiseaseSleep Quality

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.