Evidence map›Paper›PMID 41148427›Full record

ArticleInternational ophthalmology2025

The effect of micropulse transcleral cyclophotocoagulation (MP-TSCPC) on anterior segment properties in glaucoma and ocular hypertension patients.

Arij Daas, Ananth Ranjit, Thomas Sherman, Bhavin Patel, Elizabeth Galvis, Andrew Amon, Zoe Clarkson, Kin Sheng Lim

Abstract read
In one paragraph

Article in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Arij DaasDepartment of Ophthalmology, Guy's and St Thomas' NHS Foundation Trust, London, SE1 7EH, UK.
Ananth RanjitDepartment of Ophthalmology, Guy's and St Thomas' NHS Foundation Trust, London, SE1 7EH, UK.
Thomas ShermanDepartment of Ophthalmology, Guy's and St Thomas' NHS Foundation Trust, London, SE1 7EH, UK.
Bhavin PatelDepartment of Ophthalmology, Guy's and St Thomas' NHS Foundation Trust, London, SE1 7EH, UK.
Elizabeth GalvisFrost Eye Research Department, King's College London, London, SE1 7EH, UK.
Andrew AmonFrost Eye Research Department, King's College London, London, SE1 7EH, UK.
Zoe ClarksonFrost Eye Research Department, King's College London, London, SE1 7EH, UK.
Kin Sheng LimDepartment of Ophthalmology, Guy's and St Thomas' NHS Foundation Trust, London, SE1 7EH, UK. shenglim@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMicropulse Transcleral Cyclophotocoagulation (MP-TSCPC) lowers intraocular pressure by directing bursts of energy at the ciliary body which leads to a reduction in aqueous production. Although the diode laser radiation has a propensity for melanin in the ciliary epithelium, some energy dissipates into surrounding tissues. This study aims to investigate the ocular effects of MP-TSCPC on patients with glaucoma, focusing on corneal biomechanics, endothelial cell count, and refractive outcomes.

methodsPatients with open angle glaucoma and ocular hypertension were enrolled. Comprehensive ophthalmic investigations, including endothelial cell count, corneal topography, pupil diameter, and refraction, were conducted at baseline and six months post-MP-TSCPC.

resultsThirty-one eyes of 31 patients were included. At six months post-MP-TSCPC, a 2% decrease in corneal endothelial cell density was noted, though not statistically significant. A modest hyperopic shift in spherical equivalent was observed at 6 months and initially reached statistical significance. However, this did not remain significant following adjustment for multiple comparisons. Three patients had a significant hypermetropic shift. There was a statistically significant increase in pupil diameter.

conclusionThis is the first study to review various ocular parameters following micropulse transcleral cyclophotocoagulation. Overall, there was minimal clinically significant impact on ocular parameters.

Indexed as

Anterior Eye SegmentCiliary BodyGlaucoma, Open-AngleIntraocular PressureLaser CoagulationLasers, SemiconductorOcular HypertensionAgedCorneal TopographyFemaleFollow-Up StudiesHumansMaleMiddle AgedProspective StudiesRefraction, OcularGlaucomaMicropulseOcular biomechanics

Identifiers

PMID41148427
PMCPMC12568817

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.