Evidence map›Paper›PMID 41148413›Full record

ArticleWorld journal of microbiology & biotechnology2025

The effects and potential mechanisms of statins on growth, development and pathogenicity in Botrytis cinerea.

Yang Peng, Xiu Li, Zhen Gao, Ruilong Wang, Xina Wu, Yan Sun, Xinhang Li, Xinyu Yang

Abstract read
PubMed Publisher
In one paragraph

Article in World journal of microbiology & biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yang PengCollege of Plant Protection, Shenyang Agricultural University, Shenyang, Liaoning, 110866, China.
Xiu LiCollege of Plant Protection, Shenyang Agricultural University, Shenyang, Liaoning, 110866, China.
Zhen GaoCollege of Plant Protection, Shenyang Agricultural University, Shenyang, Liaoning, 110866, China.
Ruilong WangCollege of Plant Protection, Shenyang Agricultural University, Shenyang, Liaoning, 110866, China.
Xina WuCollege of Plant Protection, Shenyang Agricultural University, Shenyang, Liaoning, 110866, China.
Yan SunCollege of Plant Protection, Shenyang Agricultural University, Shenyang, Liaoning, 110866, China.
Xinhang LiCollege of Plant Protection, Shenyang Agricultural University, Shenyang, Liaoning, 110866, China.
Xinyu YangCollege of Plant Protection, Shenyang Agricultural University, Shenyang, Liaoning, 110866, China. yangxy@syau.edu.cn.ORCID http://orcid.org/0000-0001-8927-0565

Funding

Basic Scientific Research program of the Educational Department of Liaoning province JYTMS20231277
6 · The paper itself

Abstract

Statins that target HMG-CoA reductase (HMGR) in the mevalonate pathway have been used to inhibit cholesterol biosynthesis. Therefore, they have the potential as inhibitors targeting the sterol biosynthesis pathway of plant pathogenic fungi. Currently, their activity against Botrytis cinerea is unknown. In this study, we determined the effects of four statins on both development and pathogenicity of B. cinerea. The interaction modes between statins and HMGR in B. cinerea were characterized through qRT-PCR and molecular docking analysis. Fluvastatin, atorvastatin, simvastatin and lovastatin strongly suppressed hyphal growth of B. cinerea, with EC

Indexed as

BotrytisHydroxymethylglutaryl-CoA Reductase InhibitorsAtorvastatinFluvastatinFungal ProteinsGene Expression Regulation, FungalHydroxymethylglutaryl CoA ReductasesHyphaeLovastatinMolecular Docking SimulationPlant DiseasesSimvastatinSpores, FungalVirulenceAtorvastatinFluvastatinFungal ProteinsHydroxymethylglutaryl-CoA Reductase InhibitorsHydroxymethylglutaryl CoA ReductasesLovastatinSimvastatinAntifungal activityB. cinereaGray mold diseaseHMG-CoA reductaseMolecular dockingStatin inhibitors

Identifiers

PMID41148413

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.