ReviewJournal of neurology2025
Glucocorticoid-induced myopathy: a comprehensive review.
Review in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGlucocorticoid-induced myopathy (GIM) is a prevalent and often underdiagnosed condition that significantly impacts the quality of life and functional capabilities of affected individuals. This review summarises the current understanding of GIM, focussing on its pathophysiology, diagnostic challenges, and emerging therapeutic strategies.
methodsA comprehensive review of the literature was conducted to identify relevant studies on GIM. Databases, such as PubMed, Embase, and Web of Science, were searched using keywords related to GIM, pathophysiology, diagnosis, and treatment. Studies were selected based on their relevance to the topic and the quality of their methodologies.
resultsGIM is characterised by proximal muscle weakness, atrophy, persistent fatigue, and reduced muscular endurance, predominantly affecting the lower limbs. The pathophysiology involves both catabolic and anti-anabolic mechanisms, leading to the degradation of muscle proteins and inhibiting protein synthesis. Diagnostic challenges include the nonspecific nature of symptoms and the lack of sensitive biomarkers. Emerging therapeutic strategies include the use of growth hormones, insulin-like growth factor-1, branched-chain amino acids, and creatine although their efficacy in humans requires further validation. Physical therapy, particularly resistance and aerobic exercise, has shown promise in managing GIM.
conclusionsThe diagnosis and management of GIM require a multifaceted approach, including early diagnosis, optimised corticosteroid use, and targeted therapies. Future research should focus on developing improved biomarkers for early detection, exploring genetic susceptibility, and validating the efficacy of emerging therapeutic interventions to improve outcomes for patients with GIM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.