ArticleExperimental brain research2025
Bupivacaine exacerbates postoperative cognitive dysfunction by suppressing YES1-mediated YAP1 phosphorylation.
Article in Experimental brain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bupivacaine is a commonly used local anesthetic in both human and equine medicine. This study aimed to explore the molecular mechanism of bupivacaine-induced postoperative cognitive dysfunction (POCD). Bioinformatics analysis identified YES proto-oncogene 1 (YES1) as a key player. A POCD mouse model was developed using bupivacaine and surgery, followed by assessment of cognitive function and DNA damage. SH-SY5Y cells were exposed to bupivacaine, and DNA damage was analyzed. Verteporfin, a Yes-associated protein 1 (YAP1) inhibitor, was used in both mice and cells to study its effects. Bupivacaine increased escape latency and decreased the number of platform crossings in the Morris water maze test, and reduced total distance traveled in the open field test and discrimination index in the novel object recognition test, which was associated with the suppression of YES1 expression in the hippocampal tissue of mice. YES1 overexpression alleviated POCD and neuronal DNA damage induced by bupivacaine in mice by promoting YAP1 phosphorylation. Treatment with verteporfin reversed the alleviating effects of YES1 overexpression on neuronal DNA damage and exacerbated POCD in mice. In conclusion, bupivacaine induces POCD by suppressing YES1 expression and YAP1 phosphorylation, leading to DNA damage.
Indexed as
Identifiers
41148350What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.