ArticleEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2025
Characteristics, treatments, and outcomes of patients with necrotizing soft tissue infections: a Dutch multicenter cohort study.
Article in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Multifocal necrotizing fasciitis: what makes it different? A German trauma center experience.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- A Case ofClinical case reports · 2026Article
- Factors associated with in-hospital mortality in necrotising soft tissue infections. a multicentre retrospective cohort study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
purposeNecrotizing Soft Tissue Infections (NSTI) are associated with high mortality and morbidity. This study aimed to gain insights into the patient-, disease-, and treatment characteristics, as well as the clinical outcomes of NSTI patients in the Netherlands, contributing to the global knowledge of this disease.
methodsThis study analyzed the NSTI Knowledge Project cohort, comprising 271 patients who were treated for acute NSTI in 11 hospitals across the Netherlands between 2013 and 2017.
resultsMost patients (61%) presented with early-stage NSTI symptoms, such as pain or erythema. Intensive care unit admission was required in 83%, with a median stay of 5 days (interquartile range 2-11). The median time from hospital admission to debridement was 8 h (interquartile range 4-23). Group A Streptococcus was cultured in 41% of patients. Extremity amputation was required in 12%, and the in-hospital mortality rate was 21%. Patients presenting with early-stage symptoms who were misdiagnosed (60%) had a significantly higher in-hospital mortality rate (30%) than those correctly diagnosed (10%; p = .003).
conclusionIn the Netherlands, NSTI patient and disease characteristics vary considerably. With one in five patients dying and one in eight patients undergoing a major amputation, interventions leading to rapid diagnosis and treatment are urgently needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.