Evidence map›Paper›PMID 41148307›Full record

ArticleCellular and molecular life sciences : CMLS2025

Sorcin regulates alveolarization and airway tissue remodeling during lung morphogenesis.

Claudia Tito, Luciana De Angelis, Alessia Iaiza, Annalisa Pia Abbinantefina, Anna Benedetti, Gilla Mazzanti, Vincenzo Petrozza, Mattia Lauriola, Luca Tamagnone, Andrea Ilari and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Claudia TitoDepartment of Anatomical, Histological, Forensic & Orthopaedic Sciences, Section of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy.
Luciana De AngelisDepartment of Anatomical, Histological, Forensic & Orthopaedic Sciences, Section of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy.
Alessia IaizaDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
Annalisa Pia AbbinantefinaDepartment of Anatomical, Histological, Forensic & Orthopaedic Sciences, Section of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy.
Anna BenedettiTranslational Oncology Research Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Gilla MazzantiDepartment of Anatomical, Histological, Forensic & Orthopaedic Sciences, Section of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy.
Vincenzo PetrozzaDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
Mattia LauriolaDepartment of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.
Luca TamagnoneDepartment of Life Science and Public Health, Histology and Embryology Unit, Catholic University of the Sacred Hearth, Rome, Italy.
Andrea IlariInstitute of Molecular Biology and Pathology, Italian National Research Council, IBPM-CNR, Rome, Italy.
Silvia MasciarelliDepartment of Anatomical, Histological, Forensic & Orthopaedic Sciences, Section of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy.
Gianni ColottiInstitute of Molecular Biology and Pathology, Italian National Research Council, IBPM-CNR, Rome, Italy. gianni.colotti@cnr.it.
Francesco FaziDepartment of Anatomical, Histological, Forensic & Orthopaedic Sciences, Section of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy. francesco.fazi@uniroma1.it.ORCID http://orcid.org/0000-0003-2910-7912

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca PRIN_2022PNRR Prot. P2022C948RMinistero dell'Istruzione, dell'Università e della Ricerca PRIN_2022 Prot. 2022WB59LBMinistero dell'Università e della Ricerca PRIN 2022 MUR 2022HYF8KS
6 · The paper itself

Abstract

Sorcin, a key calcium-sensing protein, regulates calcium concentration within the endoplasmic reticulum (ER), promoting apoptosis resistance and ER stress. It also modulates downstream signaling pathways of the epidermal growth factor receptor (EGFR), influencing cellular migration and invasion in non-small-cell lung carcinoma (NSCLC) cell lines. For this purpose, this study investigates the relationship between Sorcin and EGFR expression during lung development at the physiological level. Our study was conducted on WT and Sorcin Knock-out (Sri

Indexed as

Airway RemodelingCalcium-Binding ProteinsLungMorphogenesisPulmonary AlveoliAnimalsErbB ReceptorsFibroblast Growth Factor 10MiceMice, Inbred C57BLMice, KnockoutCalcium-Binding ProteinsErbB ReceptorsFibroblast Growth Factor 10Airway remodelingAlveolarizationBranching morphogenesisLung developmentSorcin KO

Identifiers

PMID41148307
PMCPMC12569328

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.