Evidence map›Paper›PMID 41148290›Full record

ArticleNeuroradiology2026

Non-Contrast CT versus CT perfusion for predicting post-thrombectomy outcomes in anterior circulation large vessel occlusion stroke.

Yuan Ma, Yifu Liu, Minqiang Tang, Xinglong Liu, Guangdong Lu, Kai Qiu, Chun Zhou, Linbo Zhao, Yuezhou Cao, Sheng Liu and 2 more

Abstract readMulticenter StudyComparative Study
PubMed Publisher
In one paragraph

Article in Neuroradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yuan MaThe First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Yifu LiuThe First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Minqiang TangThe First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Xinglong LiuThe First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Guangdong LuThe First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Kai QiuThe First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Chun ZhouThe First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Linbo ZhaoThe First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Yuezhou CaoThe First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Sheng LiuThe First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Haibin ShiThe First Affiliated Hospital with Nanjing Medical University, Nanjing, China. shihb@njmu.edu.cn.
Zhenyu JiaThe First Affiliated Hospital with Nanjing Medical University, Nanjing, China. zhenyu_jia@sina.com.

Funding

Jiangsu Province Capability Improvement Project through Science Technology and Education JSDW202243Jiangsu Province Key Research and Development Plan of Social Development BE2022809National Natural Science Foundation of China 82472085
6 · The paper itself

Abstract

purposeWhile CT perfusion (CTP) is the current standard for endovascular thrombectomy (EVT) selection in extended time windows with acute ischemic stroke with large vessel occlusion (LVO-AIS), the added prognostic value of CTP over non-contrast CT (NCCT)-based models remains debated, particularly when combined with clinical variables.

methodsIn this dual-center retrospective cohort study, we analyzed 216 consecutive anterior circulation LVO-AIS patients undergoing EVT between May 2021 and March 2024. Univariate and multivariate analysis were performed on both NCCT-derived and CTP-derived imaging parameters alongside clinical variables, with 90-day functional independence (modified Rankin Scale [mRS] 0-2) as primary endpoint. The ROC curves of the two models were computed using 5-fold cross-validation, and differences in the area under the curve (AUC) were evaluated using DeLong's test.

resultsFunctional independence (mRS 0-2) was achieved in 42.6% (92/216) of the patients. The NCCT-clinical model incorporated ASPECTS, baseline NIHSS and diabetes status, and the CTP-clinical model incorporated ischemic core volume, baseline NIHSS and diabetes status. The NCCT-clinical model demonstrated AUC of 0.819 and the CTP-clinical model 0.834. The difference of AUC showed no statistical significance​ between NCCT-clinical model and the CTP-clinical model (ΔAUC = 0.015, P = 0.964). The NCCT-clinic model demonstrated comparable performance to CTP-clinic model, including accuracy (74.0% vs. 75.8%), sensitivity (80.5% vs. 82.1%) and specificity (65.7% vs. 67.7%).

conclusionThe NCCT-clinical model achieved comparable ability to predict prognosis compared to the CTP-clinical model in extended time windows with LVO-AIS.

Indexed as

Ischemic StrokeThrombectomyTomography, X-Ray ComputedAgedAged, 80 and overFemaleHumansMaleMiddle AgedPredictive Value of TestsPrognosisRetrospective StudiesTreatment OutcomeAcute ischemic strokeCT perfusionMechanical thrombectomyNon-contrast CT

Identifiers

PMID41148290

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.