ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2026
The higher cellular elastic modulus of the nucleus pulposus with degenerative changes in the cervical intervertebral discs.
Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
Abstract
purposeOur study aims to explore the association between the elastic modulus of nucleus pulposus cells (NPCs) and degenerative changes in the cervical intervertebral discs (IVDs).
methodsPrimary human NPCs were isolated from 21 degenerative IVDs that underwent anterior cervical decompression and fusion. The clinical degeneration degree of IVDs were assessed by a qualitative approach based on MRIs and a quantitative method based on the radiographs after all elastic modulus of NPCs were measured. On the basis of the degree of cervical IVDs degeneration, subjects were divided into mild (n = 6), moderate (n = 10) and severe (n = 5) degeneration groups. Atomic force microscopy were used to acquire morphology and force displacement curves. Force curves were fitted using the Sneddon model to extract the cellular elastic modulus.
resultsIn our study, the elastic modulus increased significantly in mild, moderate, and severe groups (46.75 ± 17.87, 50.34 ± 25.97, and 72.63 ± 25.82 kPa, respectively) in accordance with the degree of cervical IVD degeneration (P < 0.05). In particularly, when the degree of height loss was enhanced because of IVD degeneration, the elastic modulus was also significantly increased in the groups (45.24 ± 19.90, 53.39 ± 26.78, and 70.68 ± 25.43 kPa, respectively; P < 0.05).
conclusionsThe micromechanics of NPCs was associated with the macroscopic behavior in the IVDs. The cellular elastic modulus of NPCs, which could be influenced by age, sex and IVD segment of the subjects, increased with the aggravation of IVDs degeneration and the reduction of discs height.
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