Evidence map›Paper›PMID 41148253›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

Positive inotropic effects of serotonin in atrial EHT: further proof for an atrial phenotype?

Muhammed Sönmez, Margaret Nandudu, Paul Brunnbauer, Carl Schulz, Birgit Klampe, Thomas Schulze, Arne Hansen, Thomas Eschenhagen, Torsten Christ

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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Muhammed SönmezUniversity Medical Center Hamburg-Eppendorf, Institute of Experimental Pharmacology and Toxicology, Martinistraße 52, 20246, Hamburg, Germany.
Margaret NanduduUniversity Medical Center Hamburg-Eppendorf, Institute of Experimental Pharmacology and Toxicology, Martinistraße 52, 20246, Hamburg, Germany.
Paul BrunnbauerUniversity Medical Center Hamburg-Eppendorf, Institute of Experimental Pharmacology and Toxicology, Martinistraße 52, 20246, Hamburg, Germany.
Carl SchulzUniversity Medical Center Hamburg-Eppendorf, Institute of Experimental Pharmacology and Toxicology, Martinistraße 52, 20246, Hamburg, Germany.
Birgit KlampeUniversity Medical Center Hamburg-Eppendorf, Institute of Experimental Pharmacology and Toxicology, Martinistraße 52, 20246, Hamburg, Germany.
Thomas SchulzeUniversity Medical Center Hamburg-Eppendorf, Institute of Experimental Pharmacology and Toxicology, Martinistraße 52, 20246, Hamburg, Germany.
Arne HansenUniversity Medical Center Hamburg-Eppendorf, Institute of Experimental Pharmacology and Toxicology, Martinistraße 52, 20246, Hamburg, Germany.
Thomas EschenhagenUniversity Medical Center Hamburg-Eppendorf, Institute of Experimental Pharmacology and Toxicology, Martinistraße 52, 20246, Hamburg, Germany.
Torsten ChristUniversity Medical Center Hamburg-Eppendorf, Institute of Experimental Pharmacology and Toxicology, Martinistraße 52, 20246, Hamburg, Germany. t.christ@uke.de.

Funding

Deutsche Forschungsgemeinschaft's Collaborative Research Center 0714/151German Ministry of Education and Research PRAEDIKARD FKZ031L0236
6 · The paper itself

Abstract

Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) cultured in the presence of retinoic acid were proposed as a model for human atrium. Since in the human heart positive inotropic effects of serotonin (5-HT) are restricted to the atrium, we investigated whether the presence of 5-HT responses may distinguish between hiPSC-atrial and ventricular CM. Nonfiltered retinoic acid (1 µM) was used to induce an atrial phenotype (hiPSC-aCM) in two different hiPSC lines. Untreated hiPSC-CM were used as controls (ventricular). We measured 5-HT4 receptor (HTR4) expression and 5-HT effects on Ca

Indexed as

Heart AtriaInduced Pluripotent Stem CellsMyocardial ContractionMyocytes, CardiacSerotoninAction PotentialsCell LineCells, CulturedHumansPhenotypeReceptors, Serotonin, 5-HT4Tissue EngineeringReceptors, Serotonin, 5-HT4Serotonin5-HT4 receptorAction potentialCalcium currentEngineered heart tissue (EHT)Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM)Serotonin (5-HT)

Identifiers

PMID41148253
PMCPMC13046593

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.