Evidence map›Paper›PMID 41148188›Full record

ArticleMicrobial genomics2025

An integrated multi-omic approach for discovery and dereplication of bioactive microbial natural products.

Negero Gemeda Negeri, Duong Duc Anh Nguyen, Michael Michael, Emma Kenshole, Calum Walsh, Louise M Judd, Liam K R Sharkey, Weiguang Zeng, Timothy P Stinear, Marion Herisse and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbial genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Microbial solutions for a changing world.Sustainable microbiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Negero Gemeda NegeriBiomedicine Discovery Institute, Monash University, Clayton, Australia.
Duong Duc Anh NguyenDepartment of Microbiology and Immunology at the Doherty Institute, University of Melbourne, Melbourne, 3000, Australia.
Michael MichaelDepartment of Microbiology and Immunology at the Doherty Institute, University of Melbourne, Melbourne, 3000, Australia.
Emma KensholeDepartment of Microbiology and Immunology at the Doherty Institute, University of Melbourne, Melbourne, 3000, Australia.
Calum WalshDepartment of Microbiology and Immunology at the Doherty Institute, University of Melbourne, Melbourne, 3000, Australia.
Louise M JuddCentre for Pathogen Genomics, Doherty Institute, University of Melbourne, Melbourne, 3000, Australia.
Liam K R SharkeyDepartment of Microbiology and Immunology at the Doherty Institute, University of Melbourne, Melbourne, 3000, Australia.
Weiguang ZengDepartment of Microbiology and Immunology at the Doherty Institute, University of Melbourne, Melbourne, 3000, Australia.
Timothy P StinearDepartment of Microbiology and Immunology at the Doherty Institute, University of Melbourne, Melbourne, 3000, Australia.
Marion HerisseDepartment of Microbiology and Immunology at the Doherty Institute, University of Melbourne, Melbourne, 3000, Australia.
Chuan HuangBiomedicine Discovery Institute, Monash University, Clayton, Australia.
Max J CryleBiomedicine Discovery Institute, Monash University, Clayton, Australia.
Sacha J PidotDepartment of Microbiology and Immunology at the Doherty Institute, University of Melbourne, Melbourne, 3000, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Soil bacteria are a major source of clinically useful antibiotics, yet the majority of soil-dwelling micro-organisms remain uncultivable by standard laboratory methods. To access this untapped microbial diversity, we employed microbial diffusion chambers to isolate bacteria from ten Australian soil samples. A total of 1,218 bacterial isolates were recovered, representing a diverse collection spanning 61 genera from 32 families, covering the major known phyla of soil bacteria. Antibiotic activity screening revealed that 16% of isolates inhibited the growth of at least 1 of

Indexed as

Anti-Bacterial AgentsBacteriaBiological ProductsSoil MicrobiologyAustraliaEscherichia coliGenomicsMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMultigene FamilyMultiomicsStaphylococcus aureusAnti-Bacterial AgentsBiological ProductsActinobacteriasoil microbiomeStreptomyces

Identifiers

PMID41148188
PMCPMC12560952

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.