Evidence map›Paper›PMID 41148171›Full record

ArticleACS applied materials & interfaces2025

Chitosan/Alginate Polyelectrolyte Magnetic Gel Nanoarchitectonics with Tunable Mechanical Properties for Magnetic Hyperthermia and Sustained Release of 5-Fluorouracil.

Sérgio R S Veloso, Margarita Vázquez-González, Mariana O Ribeiro, Loic Hilliou, Carlos O Amorim, Vítor S Amaral, Miguel A Correa-Duarte, Elisabete M S Castanheira

Abstract read
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In one paragraph

Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sérgio R S VelosoPhysics Centre of Minho and Porto Universities (CF-UM-UP), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.
Margarita Vázquez-GonzálezCentro de Investigación en Nanomateriais e Biomedicina (CINBIO), Universidad de Vigo, 36310 Vigo, Spain.ORCID 0000-0003-0030-1180
Mariana O RibeiroPhysics Centre of Minho and Porto Universities (CF-UM-UP), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.
Loic HilliouInstitute for Polymers and Composites, Department of Polymer Engineering, University of Minho, Campus de Azurém, Guimarães, 4800-058, Portugal.
Carlos O AmorimPhysics Department and i3N, University of Aveiro, Campus de Santiago, Aveiro 3810-193, Portugal.ORCID 0000-0003-4148-4374
Vítor S AmaralPhysics Department and CICECO, University of Aveiro, Campus de Santiago, Aveiro 3810-193, Portugal.
Miguel A Correa-DuarteCentro de Investigación en Nanomateriais e Biomedicina (CINBIO), Universidad de Vigo, 36310 Vigo, Spain.ORCID 0000-0003-1950-1414
Elisabete M S CastanheiraPhysics Centre of Minho and Porto Universities (CF-UM-UP), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.ORCID 0000-0002-5829-6081

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chitosan-based hydrogels hold promise as drug delivery systems for cancer therapy, but the poor mechanical properties often limit the biological application, requiring chemical cross-linking to improve sustained drug release. Besides, the addition of stimulus-responsiveness to chitosan requires chemical modifications that can further affect the gel properties. To overcome these challenges, in this work, a novel chitosan/alginate polyelectrolyte magnetic gel with tunable mechanical properties is developed by pH-triggered self-assembly. The gels could be prepared by a slow/fast pH decrease and blended with magnetic nanoparticles. Manganese-doped ferrite nanoparticles (∼10 nm) with suitable magnetic properties (>70 Am

Indexed as

AlginatesChitosanFluorouracilMagnetite NanoparticlesPolyelectrolytesDelayed-Action PreparationsDrug CarriersDrug LiberationHumansHydrogelsHyperthermia, InducedAlginatesChitosanDelayed-Action PreparationsDrug CarriersFluorouracilHydrogelsMagnetite NanoparticlesPolyelectrolytesalginatechitosandrug deliverymagnetic gelsmagnetic hyperthermia

Identifiers

PMID41148171
PMCPMC12616591

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.