Evidence map›Paper›PMID 41148120›Full record

ArticleJournal of the American Chemical Society2025

Resistance Gene-Guided Discovery of a Fungal Spirotetramate as an Acetolactate Synthase Inhibitor.

Tsz Ki Chan, Xingxing Wei, Li Ma, Hang Wang, Pan Liao, Yudai Matsuda

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tsz Ki ChanDepartment of Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China.ORCID 0009-0004-3883-7727
Xingxing WeiDepartment of Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China.ORCID 0000-0002-1819-6983
Li MaDepartment of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China.ORCID 0009-0007-2164-1121
Hang WangSchool of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.ORCID 0000-0001-7706-0536
Pan LiaoDepartment of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China.ORCID 0000-0002-1156-8916
Yudai MatsudaDepartment of Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China.ORCID 0000-0001-5650-4732

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biosynthetic gene clusters (BGCs) of bioactive natural products occasionally encode resistant versions of the proteins they inhibit, offering opportunities for resistance gene-guided genome mining to uncover natural products with predictable modes of action. In this study, we developed a genome mining tool designed to identify fungal BGCs harboring putative resistance genes. Applying this tool to approximately 2500 fungal genomes, we identified a BGC designated as the

Indexed as

Acetolactate SynthaseAntifungal AgentsDrug DiscoveryEnzyme InhibitorsSpiro CompoundsMultigene FamilyAcetolactate SynthaseAntifungal AgentsEnzyme InhibitorsSpiro Compounds

Identifiers

PMID41148120
PMCPMC12616698

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.