Evidence map›Paper›PMID 41147884›Full record

ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2026

Kinematic alignment, but not mechanical alignment, preserves the knee-ankle relationship after total knee arthroplasty: A retrospective radiographic analysis from the FP-UCBM Knee Study Group.

Edoardo Franceschetti, Giancarlo Giurazza, Marco Donantoni, Stefano Campi, Andrea Tanzilli, Pietro Gregori, Michele Paciotti, Biagio Zampogna, Andrea Marinozzi, Umile Giuseppe Longo and 1 more

Abstract readComparative Study
In one paragraph

Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Edoardo FranceschettiFondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy.
Giancarlo GiurazzaFondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy.ORCID https://orcid.org/0000-0003-4385-6813
Marco DonantoniFondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy.ORCID https://orcid.org/0009-0004-0361-4443
Stefano CampiFondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy.
Andrea TanzilliFondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy.
Pietro GregoriFondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy.
Michele PaciottiFondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy.
Biagio ZampognaFondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy.
Andrea MarinozziFondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy.
Umile Giuseppe LongoFondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy.
Rocco PapaliaFondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSeveral alignment strategies have been proposed in total knee arthroplasty (TKA), with the two extremes being mechanical alignment (MA) and unrestricted kinematic alignment (KA). While MA standardises coronal knee parameters to achieve a neutral alignment, KA reproduces each patient's native joint lines. The impact of these strategies on the ankle joint remains poorly understood. The aim of this study was to compare the effects of MA and KA on coronal ankle alignment, hypothesising that MA induces greater alterations than KA.

methodsIn this retrospective cohort study, 208 consecutive TKA cases, performed with either MA (n = 104) or unrestricted KA (n = 104) were included. Preoperative and 1-year postoperative full-length standing radiographs were analysed for lateral distal femoral angle (LDFA), medial proximal tibial angle (MPTA), hip-knee-ankle angle (HKA), Coronal-Plane-Alignment-of-the-Knee (CPAK) categories and ankle-specific parameters: talar inclination (TI), tibial plafond inclination (TPI), and talar tilt (TT). Changes in radiographic parameters (Δ) were calculated as the difference between 1-year postoperative and preoperative values. Within-group and between-group changes were assessed with paired and independent t-tests, respectively, and correlations between knee and ankle changes were calculated. Statistical significance was set at p < 0.05.

resultsMA resulted in significant postoperative changes in TI (-3.21 ± 3.28°; p < 0.001) and TPI (-2.62 ± 3.16°; p < 0.001), whereas KA produced no significant changes (TI: -0.60 ± 3.54°, TPI: -0.18 ± 3.23°; p > 0.05). No significant changes were observed for TT in either group. In the MA group, ΔTPI correlated moderately with ΔHKA, ΔLDFA, and ΔMPTA. Pre/postoperative changes in CPAK category did not show any impact on coronal ankle parameters following TKA (p > 0.05)

conclusionsCoronal ankle alignment is preserved by unrestricted KA but altered by MA. These findings suggest that KA minimises unintended ankle alterations, maintaining the patient-specific knee-ankle relationship and potentially reducing the risk of secondary ankle malalignment or degeneration following TKA. LEVEL OF EVIDENCE: Level IV retrospective analysis.

Indexed as

Ankle JointArthroplasty, Replacement, KneeBone MalalignmentKnee JointOsteoarthritis, KneeAgedBiomechanical PhenomenaFemaleHumansMaleMiddle AgedRadiographyRetrospective Studiescoronal ankle alignmentkinematic alignmentknee–ankle relationshipmechanical alignmenttotal knee arthroplasty

Identifiers

PMID41147884
PMCPMC13327440

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.