In one paragraphArticle in Aging cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
18 authors.
Raquel R MartinsSchool of Medicine and Population Health, Bateson Centre for Disease Mechanisms and Healthy Lifespan Institute (HELSI), University of Sheffield, Sheffield, UK.ORCID 0000-0003-3952-8649 Pam S EllisSchool of Medicine and Population Health, Bateson Centre for Disease Mechanisms and Healthy Lifespan Institute (HELSI), University of Sheffield, Sheffield, UK.ORCID 0000-0002-5915-4739 Naomi HartoppSheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK.ORCID 0000-0003-4069-6324 Catherine PurseSchool of Medicine and Population Health, Bateson Centre for Disease Mechanisms and Healthy Lifespan Institute (HELSI), University of Sheffield, Sheffield, UK.
Georgia Everett-BrownSchool of Medicine and Population Health, Bateson Centre for Disease Mechanisms and Healthy Lifespan Institute (HELSI), University of Sheffield, Sheffield, UK.
Owain EvansSchool of Medicine and Population Health, Bateson Centre for Disease Mechanisms and Healthy Lifespan Institute (HELSI), University of Sheffield, Sheffield, UK.ORCID 0009-0000-8493-4983 Nadiyah MughalSchool of Medicine and Population Health, Bateson Centre for Disease Mechanisms and Healthy Lifespan Institute (HELSI), University of Sheffield, Sheffield, UK.
Mina H F WahibSchool of Medicine and Population Health, Bateson Centre for Disease Mechanisms and Healthy Lifespan Institute (HELSI), University of Sheffield, Sheffield, UK.
Zerkif YaziganSchool of Medicine and Population Health, Bateson Centre for Disease Mechanisms and Healthy Lifespan Institute (HELSI), University of Sheffield, Sheffield, UK.
Samir MorsliSchool of Medicine and Population Health, Bateson Centre for Disease Mechanisms and Healthy Lifespan Institute (HELSI), University of Sheffield, Sheffield, UK.
Ada Jimenez-GonzalezSheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK.ORCID 0000-0001-7702-6135 Andrew GriersonSheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK.ORCID 0000-0001-7039-6731 Heather MortiboysSheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK.ORCID 0000-0001-6439-0579 Chrissy HammondSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.ORCID 0000-0002-4935-6724 Catarina M HenriquesSchool of Medicine and Population Health, Bateson Centre for Disease Mechanisms and Healthy Lifespan Institute (HELSI), University of Sheffield, Sheffield, UK.ORCID 0000-0003-1882-756X Funding
ANR ADAGIO ANR-20-CE44-0010Biotechnology and Biological Sciences Research Council BB/Y002504/1Conseil National de la Recherche ScientifiqueThe University of Sheffield Vice Chancellor's FellowshipVivensa AISRPG2305\32Wellcome TrustWellcome Trust 206224/Z/17/Z/WT
6 · The paper itselfAbstract
Decreased telomerase expression, telomere shortening, senescence-associated markers, and inflammation have all been independently observed in the ageing brain and associated with disease. However, causality between limited telomerase expression and brain senescence and neuro-inflammation in the natural ageing setting is yet to be established. Here, we address these questions using the zebrafish as an ageing model. Akin to humans, zebrafish display premature ageing and death in the absence of telomerase and telomere shortening is a driver of cellular senescence. Our work shows for the first time that telomerase deficiency (tert
Indexed as
AgingBrainTelomeraseZebrafishAnimalsCellular SenescenceTelomeraseageingbehaviourblood–brain barrier (BBB)braininflammationsenescencetelomeraseTERTtranscriptomicszebrafish
Identifiers
PMID41147684
PMCPMC12686574
What OpenQuestion holds
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LicenceCC BY
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