SynthesisClinical and experimental dental research2025
Preventive and Therapeutic Effects of Plant-Derived Compounds on Tooth Erosion: A Systematic Review and Meta-Analysis of In Situ and In Vitro Studies.
Synthesis in Clinical and experimental dental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Preventive and Therapeutic Effects of Plant-Derived Compounds on Tooth Erosion: A Systematic Review and Meta-Analysis of In Situ and In Vitro Studies.Clinical and experimental dental research · 2025Pooled it
- Do polyphenol-rich solutions derived from tropical fruit seeds protect dentin against erosive-abrasive challenges?Clinical oral investigations · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectivesTooth erosion is the nonbacterial and irreversible pathological dissolution of enamel and dentin, and is primarily influenced by lifestyle. This systematic review and meta-analysis aimed to evaluate the preventive and therapeutic effects of plant-derived compounds on tooth erosion using evidence from in vitro and in situ studies. MATERIALS AND
methodsThe review was registered in PROSPERO (CRD42023493906) and search was performed in PubMed, Scopus, ISI Web of Science, and Embase databases until July 5, 2025. In vitro and in situ original studies that investigated the effects of plant-based interventions on dental erosion, with a control group, were included. In vivo studies and those plants combined with non-plant substances were excluded. Risk of bias was assessed using the QUIN tool. Meta-analyses were performed when appropriate. Mechanical and ultrastructure assessments used to evaluate surface loss, hardness, and morphological changes were also reviewed.
resultsOut of 1119 studies, 38 studies met the inclusion criteria; 22 studies assessed preventive effects, and 18 assessed the therapeutic effects, and one study that evaluated both the effects. Most studies had a medium risk of bias. Meta-analysis showed that quercetin as a preventive measure, significantly reduced dentin loss by 4.95 µm with high heterogeneity (I
conclusionsPlants with polyphenols may modify the pellicle layer ultrastructure to protect teeth from erosion. Quercetin (the most common flavonoid in fruit and vegetables) has preventive and therapeutic effects on dentin erosion. Green tea (because of its elevated catechin content) has therapeutic effects on dentin erosion.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.