Evidence map›Paper›PMID 41147582›Full record

ArticleeLife2025

The Rab7-Epg5 and Rab39-ema modules cooperatively position autophagosomes for efficient lysosomal fusions.

Attila Boda, Villő Balázs, Anikó Nagy, Dávid Hargitai, Mónika Lippai, Zsófia Simon-Vecsei, Márton Molnár, Fanni Fürstenhoffer, Gábor Juhász, Péter Lőrincz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Attila BodaDepartment of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary.ORCID https://orcid.org/0000-0003-1811-8595
Villő BalázsDepartment of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary.
Anikó NagyDepartment of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary.
Dávid HargitaiDepartment of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary.
Mónika LippaiDepartment of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary.
Zsófia Simon-VecseiDepartment of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary.ORCID https://orcid.org/0000-0001-7909-4895
Márton MolnárDepartment of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary.
Fanni FürstenhofferDepartment of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary.
Gábor JuhászDepartment of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary.ORCID https://orcid.org/0000-0001-8548-8874
Péter LőrinczDepartment of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary.ORCID https://orcid.org/0000-0001-7374-667X

Funding

Eötvös Loránd Tudományegyetem EKA 2022/045-P101-2Magyar Tudományos Akadémia LP2022-13/2022Magyar Tudományos Akadémia LP2023-6National Research, Development and Innovation Office DKÖP-2023-ELTE-13National Research, Development and Innovation Office FK138851National Research, Development and Innovation Office KKP129797National Research, Development and Innovation Office PD142943National Research, Development and Innovation Office ÚNKP-23-3-I-ELTE-706National Research, Development and Innovation Office ÚNKP-23-3-I-ELTE-724
6 · The paper itself

Abstract

Macroautophagy, a major self-degradation pathway in eukaryotic cells, utilizes autophagosomes to transport self-material to lysosomes for degradation. While microtubular transport is crucial for the proper function of autophagy, the exact roles of factors responsible for positioning autophagosomes remain incompletely understood. In this study, we performed a loss-of-function genetic screen targeting genes potentially involved in microtubular motility. A genetic background that blocks autophagosome-lysosome fusions was used to accurately analyze autophagosome positioning. We discovered that pre-fusion autophagosomes move towards the non-centrosomal microtubule organizing center (ncMTOC) in

Indexed as

AutophagosomesDrosophila melanogasterDrosophila ProteinsLysosomesrab GTP-Binding ProteinsAnimalsAutophagyDyneinsMicrotubule-Organizing Centerrab7 GTP-Binding ProteinsDrosophila ProteinsDyneinsrab7 GTP-Binding Proteinsrab GTP-Binding Proteinsautophagosomecell biologyD. melanogasterdyneinfusionlysosomemicrotubular transportncMTOC

Identifiers

PMID41147582
PMCPMC12563567

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.