Evidence map›Paper›PMID 41147516›Full record

SynthesisAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Psychometric properties of the NIH Toolbox Cognition Battery composites in older adults at risk for Alzheimer's disease and related dementias: A systematic review.

Amy B Thomas, Allison L Matthews, Olivia Brooks, Anna Winquist, Lonnie A Nelson, Randi Arias-Fontenot, Dedra Buchwald, Kaitlin B Casaletto, Sandra Weintraub, Robert K Heaton and 3 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Amy B ThomasCollege of Nursing, Washington State University, Spokane, Washington, USA.ORCID 0000-0002-8453-1161
Allison L MatthewsDepartment of Psychology, Washington State University-Tri Cities, Richland, Washington, USA.
Olivia BrooksWashington State University Elson S. Floyd College of Medicine, Spokane, Washington, USA.
Anna WinquistCollege of Nursing, University of Colorado, Aurora, Colorado, USA.
Lonnie A NelsonPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Randi Arias-FontenotCollege of Nursing, Washington State University, Spokane, Washington, USA.
Dedra BuchwaldDepartment of Neurological Surgery, University of Washington, Seattle, Washington, USA.
Kaitlin B CasalettoMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California, USA.
Sandra WeintraubMesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Robert K HeatonDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Brian F FrenchCollege of Education, Washington State University, Pullman, Washington, USA.
Astrid Suchy-DiceySlone Epidemiology Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Celestina Barbosa-LeikerCollege of Health and Human Development, California State University, Fullerton, California, USA.

Funding

University of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI Amanda D. Boyd · 2020 to 2026
$29.0M
Psychological risk factors, quality of life, community, and brain aging in American Indians: The Strong Heart StudyRF1AG071677 · NIA · WASHINGTON STATE UNIVERSITY · PI SUCHY-DICEY, ASTRID M · 2021 to 2021
$1.7M
Psychological risk factors, quality of life, community, and brain aging in American Indians: The Strong Heart StudyR01AG071677 · NIA · HUNTINGTON MEDICAL RESEARCH INSTITUTES · PI Astrid M Suchy-Dicey · 2025 to 2026
$1.2M
National Institute of Health/National Institute on Aging 1RF1AG071677-01NIA NIH HHS P30 AG066509NIA NIH HHS R01 AG071677NIA NIH HHS RF1 AG071677
6 · The paper itself

Abstract

This systematic review evaluated the psychometric performance of the National Institutes of Health's Toolbox Cognition Battery (NIHTB-CB) composite scores in older adults with and without Alzheimer's disease and related dementias (ADRD). A systematic literature search was conducted using MEDLINE, Embase, PsycINFO, and CINHAL databases. The evidence quality of NIHTB-CB measurement properties was assessed using integrated Consensus-based Standards for the Selection of Health Measurement Instrument (COSMIN) methodology and the Interpretation/Use Argument framework. Fourteen studies met inclusion criteria for this review of the NIHTB-CB. Evidence supporting the scoring, generalization, and extrapolation inferences of the Total, Crystallized, and Fluid composite scores in older adults ranged from developing through exemplary ratings. Findings indicate additional research is warranted on the NIHTB-CB in older adult and ADRD populations. The present study highlights the importance of continued use and research of the NIHTB-CB in diverse, older populations who are at risk for ADRD. HIGHLIGHTS: Limited research focuses on the National Institutes of Health's Toolbox Cognition Battery (NIHTB-CB) composites in older adults. The general psychometric robustness of the NIHTB-CB has been es. The Crystallized composite shows proficient psychometric evidence. The psychometric evidence of Fluid composite is developing due to limited data.

Indexed as

Alzheimer DiseaseCognitionDementiaNeuropsychological TestsPsychometricsAgedHumansNational Institutes of Health (U.S.)United StatesAlzheimer's disease and related dementiasNational Institutes of Health Toolbox Cognition Batterypsychometric propertiesreliabilitysystematic reviewvalidity

Identifiers

PMID41147516
PMCPMC12560014

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.