Evidence map›Paper›PMID 41147499›Full record

ReviewChemical reviews2025

Chemical Tools to Characterize the Coordination Chemistry of Radionuclides for Radiopharmaceutical Applications.

Eszter Boros, Peter Comba, Jonathan W Engle, Charlene Harriswangler, Suzanne E Lapi, Jason S Lewis, Simona Mastroianni, Liviu M Mirica, Carlos Platas-Iglesias, Caterina F Ramogida and 2 more

Abstract readReview
In one paragraph

Review in Chemical reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Design of bifunctional pyridinophane ligands as MnInorganic chemistry frontiers · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Experimental Evidence for a Metal-Related Function of a Cyanobactin.Angewandte Chemie (International ed. in English) · 2026
    Article
  8. Complexes of DOTAM with dInorganic chemistry · 2026
    Article
  9. Stabilities of AcInorganic chemistry · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Eszter BorosDepartment of Chemistry, University of Wisconsin─Madison, Madison, Wisconsin 53706, United States.ORCID 0000-0002-4186-6586
Peter CombaUniversität Heidelberg, Anorganisch Chemisches Institut and Interdisciplinary Center for Scientific Computing, 69120 Heidelberg, Germany.ORCID 0000-0001-7796-3532
Jonathan W EngleDepartment of Medical Physics, University of Wisconsin─Madison, 1111 Highland Avenue, Madison, Wisconsin 53705, United States.ORCID 0000-0002-3399-7228
Charlene HarriswanglerCICA - Centro Interdisciplinar de Química e Bioloxía and Departamento de Química, Universidade da Coruña, Campus da Zapateira-Rúa da Fraga 10, 15008 A Coruña, Spain.ORCID 0000-0002-0500-9878
Suzanne E LapiDepartment of Radiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States.
Jason S LewisMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.ORCID 0000-0001-7065-4534
Simona MastroianniDepartment of Chemistry, Simon Fraser University, 8888 University Drive, V5A 1S6 Burnaby, British Columbia, Canada.
Liviu M MiricaDepartment of Chemistry, The Neuroscience Program, Beckman Institute for Advanced Science and Technology, Carle Illinois College of Medicine, Department of Bioengineering, Carle Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, Illinois 61801, United States.ORCID 0000-0003-0584-9508
Carlos Platas-IglesiasCICA - Centro Interdisciplinar de Química e Bioloxía and Departamento de Química, Universidade da Coruña, Campus da Zapateira-Rúa da Fraga 10, 15008 A Coruña, Spain.ORCID 0000-0002-6989-9654
Caterina F RamogidaDepartment of Chemistry, Simon Fraser University, 8888 University Drive, V5A 1S6 Burnaby, British Columbia, Canada.ORCID 0000-0003-4815-2647
Raphaël TripierUniv Brest, UMR CNRS 6521 CEMCA, 6 Avenue Victor Le Gorgeu, 29200 Brest, France.ORCID 0000-0001-9364-788X
Marianna TosatoDepartment of Chemistry, Simon Fraser University, 8888 University Drive, V5A 1S6 Burnaby, British Columbia, Canada.ORCID 0000-0002-3726-6174

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Leveraging Pb-203/212 for the Theranostic Imaging and Therapy of Prostate CancerR35CA232130 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S. · 2019 to 2025
$8.2M
Blood-Brain Barrier Permeable Multimodal Imaging Agents for Neurodegenerative DiseasesRF1AG083937 · NIA · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI MIRICA, LIVIU M. · 2023 to 2023
$1.8M
NCI NIH HHS P30 CA008748NCI NIH HHS R35 CA232130NIA NIH HHS RF1 AG083937
6 · The paper itself

Abstract

During the past decade, the advancement and approval of novel radiopharmaceuticals for clinical application has led to a resurgence of the field of radiochemistry and specifically the coordination chemistry of radionuclides. In addition to well established radionuclides, short-lived radioisotopes of other elements are becoming accessible using new isotope production methods, necessitating the development of coordination chemistry compatible with the aqueous chemistry of such elements under tracer level conditions. As radiochemistry with radioactive metal ions relevant for radiopharmaceuticals is conducted at the nano- to picomole scale, conventional chemical characterization techniques can generally not be applied. Therefore, careful consideration and interfacing of tracer-level compatible techniques and macroscopic characterization methods is required. This Review provides an in-depth survey of common, contemporary characterization strategies for the coordination chemistry of radionuclides, including case studies to demonstrate context and relevance for the prospective development of clinically translatable radiopharmaceuticals.

Indexed as

Coordination ComplexesRadioisotopesRadiopharmaceuticalsHumansCoordination ComplexesRadioisotopesRadiopharmaceuticals

Identifiers

PMID41147499
PMCPMC12746417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.