Evidence map›Paper›PMID 41147409›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

DKK3 Initially Preserves Acinar Integrity Through MEK-Fos Signaling, but Later Switches to an Oncogenic Role in Pancreatic Cancer.

Dharini Srinivasan, Elodie Roger, Lukas Perkhofer, Eleni Zimmer, Thomas F E Barth, Julia P Mosler, Anna Härle, Stephanie E Weissinger, Nadine T Gaisa, Peter Möller and 11 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Dharini SrinivasanInstitute for Molecular Oncology and Stem Cell Biology, Ulm University Hospital, 89081, Ulm, Germany.ORCID https://orcid.org/0009-0007-7968-9240
Elodie RogerInstitute for Molecular Oncology and Stem Cell Biology, Ulm University Hospital, 89081, Ulm, Germany.ORCID https://orcid.org/0000-0002-4930-6292
Lukas PerkhoferInstitute for Molecular Oncology and Stem Cell Biology, Ulm University Hospital, 89081, Ulm, Germany.
Eleni ZimmerInstitute for Molecular Oncology and Stem Cell Biology, Ulm University Hospital, 89081, Ulm, Germany.ORCID https://orcid.org/0000-0002-2510-3140
Thomas F E BarthInstitute of Pathology, Ulm University Hospital, 89081, Ulm, Germany.
Julia P MoslerInstitute for Molecular Oncology and Stem Cell Biology, Ulm University Hospital, 89081, Ulm, Germany.
Anna HärleInstitute for Molecular Oncology and Stem Cell Biology, Ulm University Hospital, 89081, Ulm, Germany.ORCID https://orcid.org/0009-0007-4843-048X
Stephanie E WeissingerInstitute of Pathology, Ulm University Hospital, 89081, Ulm, Germany.
Nadine T GaisaInstitute of Pathology, Ulm University Hospital, 89081, Ulm, Germany.
Peter MöllerInstitute of Pathology, Ulm University Hospital, 89081, Ulm, Germany.
Nico FischerDepartment of Infectious Diseases/Virology, Section Viral Vector Technologies, Medical Faculty, Heidelberg University, 69120, Heidelberg, Germany.
Chantal AllgöwerInstitute for Molecular Oncology and Stem Cell Biology, Ulm University Hospital, 89081, Ulm, Germany.
J-Matthias LöhrDepartment of Clinical Science, Intervention and Technology (CLINTEC), Pancreas Cancer Research Lab, Karolinska Institute, 141 52, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-7647-198X
Dirk GrimmDepartment of Infectious Diseases/Virology, Section Viral Vector Technologies, Medical Faculty, Heidelberg University, 69120, Heidelberg, Germany.
Thomas SeufferleinDepartment of Internal Medicine I, Ulm University Hospital, 89081, Ulm, Germany.
Stefan LiebauInstitute of Neuroanatomy & Developmental Biology INDB, 72074, Tübingen, Germany.
Ninel AzoiteiInstitute for Molecular Oncology and Stem Cell Biology, Ulm University Hospital, 89081, Ulm, Germany.
Michael K MelzerInstitute for Molecular Oncology and Stem Cell Biology, Ulm University Hospital, 89081, Ulm, Germany.
Frank ArnoldCancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.ORCID https://orcid.org/0000-0003-0025-3668
Johann GoutInstitute for Molecular Oncology and Stem Cell Biology, Ulm University Hospital, 89081, Ulm, Germany.ORCID https://orcid.org/0000-0003-0522-9800
Alexander KlegerInstitute for Molecular Oncology and Stem Cell Biology, Ulm University Hospital, 89081, Ulm, Germany.ORCID https://orcid.org/0000-0003-0592-5232

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Bausteinprogramm of Ulm University L.SBN.0193Bausteinprogramm of Ulm University L.SBN.0206Deutsche Forschungsgemeinschaft KL 2544/10-1Deutsche Forschungsgemeinschaft KL 2544/6-1Else Kröner Research School for PhysiciansNCI NIH HHS P30 CA008748University of Ulm in the Clinician Scientist Program
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is characterized by its intricate biology governed by spatiotemporal dynamics in the expression and function of specific proteins. Here, DKK3 is identified as a dynamic player with a dual role in PDAC. Using the KRAS

Indexed as

Acinar CellsAdaptor Proteins, Signal TransducingCarcinoma, Pancreatic DuctalMAP Kinase Signaling SystemPancreatic NeoplasmsProto-Oncogene Proteins c-fosAnimalsDisease Models, AnimalHumansMiceMice, KnockoutSignal TransductionAdaptor Proteins, Signal TransducingDKK3 protein, humanDkk3 protein, mouseProto-Oncogene Proteins c-fosDKK3dual roleoncogenePDACtumor suppressor

Identifiers

PMID41147409
PMCPMC12806428

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.