Evidence map›Paper›PMID 41147388›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Unique Aerofoil-Structured Microfluidics for High Throughput Lipid Nanoparticle Formulation Screening and Scale-up.

Dongsheng Liu, Mingzhi Yu, Yuguo Zhang, Allen Mathew, Tianyu Guan, Liang Yao, Xianqing Wang, Wenxin Wang, Nan Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dongsheng LiuCentre of Micro/Nano Manufacturing Technology (MNMT-Dublin), School of Mechanical & Materials Engineering, University College Dublin, Dublin, D04 V1W8, Ireland.ORCID https://orcid.org/0000-0001-8861-7555
Mingzhi YuCentre of Micro/Nano Manufacturing Technology (MNMT-Dublin), School of Mechanical & Materials Engineering, University College Dublin, Dublin, D04 V1W8, Ireland.ORCID https://orcid.org/0000-0002-0184-9888
Yuguo ZhangCentre of Micro/Nano Manufacturing Technology (MNMT-Dublin), School of Mechanical & Materials Engineering, University College Dublin, Dublin, D04 V1W8, Ireland.
Allen MathewCentre of Micro/Nano Manufacturing Technology (MNMT-Dublin), School of Mechanical & Materials Engineering, University College Dublin, Dublin, D04 V1W8, Ireland.ORCID https://orcid.org/0000-0003-1827-5267
Tianyu GuanCentre of Micro/Nano Manufacturing Technology (MNMT-Dublin), School of Mechanical & Materials Engineering, University College Dublin, Dublin, D04 V1W8, Ireland.ORCID https://orcid.org/0009-0003-0223-4222
Liang YaoCharles Institute of Dermatology, School of Medicine, University College Dublin, Dublin, D04 V1W8, Ireland.ORCID https://orcid.org/0000-0002-6000-8974
Xianqing WangCharles Institute of Dermatology, School of Medicine, University College Dublin, Dublin, D04 V1W8, Ireland.ORCID https://orcid.org/0000-0002-8702-3859
Wenxin WangCharles Institute of Dermatology, School of Medicine, University College Dublin, Dublin, D04 V1W8, Ireland.ORCID https://orcid.org/0000-0002-5053-0611
Nan ZhangCentre of Micro/Nano Manufacturing Technology (MNMT-Dublin), School of Mechanical & Materials Engineering, University College Dublin, Dublin, D04 V1W8, Ireland.ORCID https://orcid.org/0000-0001-7849-3974

Funding

Enterprise Ireland CF-2021-1635-PScience Foundation Ireland (SFI) 22/NCF/FD/10914Science Foundation Ireland (SFI) 22/NCF/FD/10914G
6 · The paper itself

Abstract

Herein, a high-throughput microfluidic platform is presented that addresses the challenges in lipid nanoparticles (LNPs) formulation screening and scale-up through the design of micromixers with unique aerofoil structures. These structures are optimized to enhance mixing and LNP formation across a wide flow rate range (0.2-50 mL min

Indexed as

High-Throughput Screening AssaysLipidsMicrofluidicsNanoparticlesHumansLiposomesLipid NanoparticlesLipidsLiposomesaerofoil structureshigh‐throughput systemlipid nanoparticlesmicrofluidicsscale‐up system

Identifiers

PMID41147388
PMCPMC12866714

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.