Evidence map›Paper›PMID 41147373›Full record

ArticleJournal of the American Heart Association2025

Trends in Bicuspid Aortic Valve-Attributable Death in the United States From 2010 to 2020.

Marco Zuin, Umberto Campia, Kim I De la Cruz, Michael Singh, Gregory Piazza

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marco ZuinDepartment of Translational Medicine University of Ferrara Ferrara Italy.ORCID 0000-0002-4559-1292
Umberto CampiaDivision of Cardiovascular Medicine Brigham and Women's Hospital, Harvard Medical School Boston MA USA.ORCID 0000-0002-7894-3565
Kim I De la CruzDivision of Cardiothoracic Surgery Department of Surgery, University of Virginia, School of Medicine Charlottesville VA USA.ORCID 0000-0003-1089-2797
Michael SinghDepartment of Cardiology Boston Children's Hospital Boston MA USA.ORCID 0000-0002-8667-9872
Gregory PiazzaDivision of Cardiovascular Medicine Brigham and Women's Hospital, Harvard Medical School Boston MA USA.ORCID 0000-0003-1407-5276

Funding

Classification and Prognostication in Pulmonary Thromboembolism Using Computed Tomography Image AnalyticsR01HL164717 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Farbod Nicholas Rahaghi · 2022 to 2026
$3.6M
NHLBI NIH HHS R01 HL164717
6 · The paper itself

Abstract

backgroundPopulation-based data on bicuspid aortic valve (BAV)-attributable mortality trends in the United States are limited. This study assessed trends in BAV-attributable death in the United States from 2010 to 2020, evaluating differences by sex, ethnicity, urbanization, and census region.

methodsData were extracted from the Centers for Disease Control and Prevention's Wide-Ranging Online Data for Epidemiologic Research system. Trends in age-adjusted mortality rates per 100 000 population were analyzed using JoinPoint regression to calculate average annual percentage change and annual percentage change, with corresponding 95% CIs.

resultsFrom 2010 and 2020, 3537 deaths were attributable to BAV, corresponding to 11.7 deaths per 100 000 population. Age-adjusted mortality rates increased linearly, with an average annual percentage change of +4.6% (95% CI, 2.8-6.5;

conclusionsBAV-attributable mortality has increased over the past decade, with significant disparities by sex, age, and region. These results highlight the critical importance of developing targeted health care approaches and enhancing strategic management techniques to address specific population BAV-related health concerns.

Indexed as

Bicuspid Aortic Valve DiseaseAdolescentAdultAgedAge DistributionCause of DeathFemaleHumansMaleMiddle AgedRisk FactorsSex DistributionSex FactorsTime FactorsUnited StatesYoung Adultbicuspid aortic valvedeathtrendvalvular heart disease

Identifiers

PMID41147373
PMCPMC12684789

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.