ArticleJournal of the American Heart Association2025
From Vessels to Cognition: Glymphatic Alterations Following Hemorrhage in Cerebral Amyloid Angiopathy Are Associated With Small Vessel Disease Burden.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- DTI-ALPS index and cognitive impairment in cerebral small vessel disease: a systematic review and meta-analysis.Frontiers in aging neuroscience · 2026Pooled it
- The Glymphatic System in Neurological Diseases: Mechanisms, Imaging Surrogates, and Translational Uncertainties.Current neurology and neuroscience reports · 2026Review
- Associations of Cognitive Impairment with Putative Glymphatic-Related Imaging Indices and Cortical Atrophy in Cerebral Amyloid Angiopathy.Biomedicines · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCerebral amyloid angiopathy-related hemorrhage is associated with both cerebral small vessel disease (CSVD) pathology and long-term cognitive decline. The role of glymphatic dysfunction in mediating this relationship remains unclear.
methodsA total of 111 participants (64 patients with cerebral amyloid angiopathy-related hemorrhage, 47 healthy controls) underwent 7T magnetic resonance imaging at a stable postintracerebral hemorrhage stage. Imaging analyses included the Analysis Along the Perivascular Space (ALPS) index derived from diffusion tensor imaging, volumetric quantification of perivascular spaces, and choroid plexus segmentation. Hierarchical regression assessed group differences and associations with CSVD markers and cognition. Mediation analyses tested whether ALPS mediated the effect of CSVD on cognition.
resultsPatients with cerebral amyloid angiopathy-related hemorrhage showed significantly enlarged perivascular spaces in white matter and total brain (both
conclusionsNoninvasively measured glymphatic dysfunction in cerebral amyloid angiopathy-related hemorrhage reflects chronic CSVD burden and contributes to cognitive decline, highlighting ALPS as a sensitive and practical functional marker.
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Registered trials
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