Evidence map›Paper›PMID 41147364›Full record

ArticleJournal of the American Heart Association2025

Effects of Combining Traditional East Asian and Conventional Western Medicine on Acute Stroke Outcomes.

Dong-Seok Gwak, Jong-Sik Lee, Dawid Schellingerhout, Jinyong Chung, Hyerin Oh, Sang-Wuk Jeong, Ji Sung Lee, Hee-Joon Bae, Mikyung Kim, Dong-Jun Choi and 1 more

Abstract readComparative Study
In one paragraph

Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dong-Seok GwakDepartment of Neurology Dongguk University Ilsan Hospital Goyang Republic of Korea.ORCID 0000-0001-7850-0804
Jong-Sik LeeDepartment of Artificial Intelligence, Graduate School Chung-Ang University Seoul Republic of Korea.
Dawid SchellingerhoutDepartments of Neuroradiology and Imaging Physics University of Texas MD Anderson Cancer Center Houston TX.ORCID 0000-0003-3659-435X
Jinyong ChungNational Priority Research Center for Stroke Goyang Republic of Korea.ORCID 0000-0001-9473-5152
Hyerin OhNational Priority Research Center for Stroke Goyang Republic of Korea.ORCID 0000-0001-5179-2480
Sang-Wuk JeongDepartment of Neurology Dongguk University Ilsan Hospital Goyang Republic of Korea.
Ji Sung LeeDepartment of Biostatistics Asan Medical Center Seoul Republic of Korea.ORCID 0000-0001-8194-3462
Hee-Joon BaeDepartment of Neurology, Seoul National University Bundang Hospital Cerebrovascular Center Seongnam Republic of Korea.ORCID 0000-0003-0051-1997
Mikyung KimDepartment of Internal Medicine Dongguk University Ilsan Oriental Hospital Goyang Republic of Korea.ORCID 0000-0002-9912-6249
Dong-Jun ChoiDepartment of Internal Medicine Dongguk University Ilsan Oriental Hospital Goyang Republic of Korea.ORCID 0000-0002-0979-2791
Dong-Eog KimDepartment of Neurology Dongguk University Ilsan Hospital Goyang Republic of Korea.ORCID 0000-0002-9339-6539

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTraditional East Asian medicine (TM) is widely used in Korea and other East Asian countries. However, the effects of TM treatment on acute ischemic stroke (AIS) outcomes remain unclear, as previous studies lacked a sufficient sample size, a consecutive series design, or a prospective outcome capture approach. We aimed to investigate whether combining TM with conventional Western medicine (CM) treatments (C+TM) leads to better outcomes after AIS, relative to CM treatment alone.

methodsWe retrospectively analyzed 2157 consecutive patients with AIS from a prospectively collected registry (2011-2021) at our center and compared the CM and C+TM groups in terms of demographics and clinical efficacy, including a 3-month favorable functional outcome (modified Rankin scale score ≤1) by performing modified Poisson regression analysis, with inverse probability of treatment weighting to balance key clinical and demographic variables, as the main analysis.

resultsMean age was 66.7±12.8 years, and 63.5% were men. Compared with patients in the CM group (n=1750), those in the C+TM group (n=407) were more likely to be women, have higher admission National Institutes of Health Stroke Scale scores, present more frequently with strokes due to large-arteryatherosclerosis or small-vessel occlusion, and have a lower prevalence of smoking history. C+TM treatment was associated with a ~40% significantly lower rate of 3-month favorable functional outcome (adjusted relative risk [RR], 0.60 [95% CI, 0.51-0.70]; RR, 0.62 [95% CI, 0.53-0.72] after inverse probability of treatment weighting; both

conclusionsTM, when integrated into CM care, may be linked to less favorable functional outcomes after AIS.

Indexed as

Ischemic StrokeMedicine, East Asian TraditionalAgedEast Asian PeopleFemaleHumansMaleMiddle AgedRegistriesRepublic of KoreaRetrospective StudiesTreatment Outcomeischemic strokeoutcometraditional medicine

Identifiers

PMID41147364
PMCPMC12684499

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.