Evidence map›Paper›PMID 41147274›Full record

ReviewCurrent neuropharmacology2026

Post-Herpetic Neuralgia: Review of Pathophysiology, Mechanisms, and Drug Treatment.

Xin Yan, Yufan He, Yuwan Yue, Chuan Zhang, Hanfeng Yang, Peilin Zhao

Abstract readReview
In one paragraph

Review in Current neuropharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xin YanNanomedicine Innovation Research and Transformation Institute, Affiliated Hospital of Clinical School of Medicine, North Sichuan Medical College, Nanchong, Sichuan, 637000, China.
Yufan HeInstitute of Neurological Diseases, Affiliated Hospital of Clinical School of Medicine, North Sichuan Medical College, Nanchong, Sichuan, 637000, China.
Yuwan YueNanomedicine Innovation Research and Transformation Institute, Affiliated Hospital of Clinical School of Medicine, North Sichuan Medical College, Nanchong, Sichuan, 637000, China.
Chuan ZhangNanomedicine Innovation Research and Transformation Institute, Affiliated Hospital of Clinical School of Medicine, North Sichuan Medical College, Nanchong, Sichuan, 637000, China.
Hanfeng YangNanomedicine Innovation Research and Transformation Institute, Affiliated Hospital of Clinical School of Medicine, North Sichuan Medical College, Nanchong, Sichuan, 637000, China.
Peilin ZhaoNanomedicine Innovation Research and Transformation Institute, Affiliated Hospital of Clinical School of Medicine, North Sichuan Medical College, Nanchong, Sichuan, 637000, China.ORCID 0000-0003-4963-6168

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Post-herpetic neuralgia (PHN) is the most common complication of Herpes zoster infection. Although numerous targeted therapeutic drugs have been developed, it is difficult to achieve a complete cure. Abnormalities in neural circuits, ion channels, inflammatory factors, and gene regulation are crucial factors contributing to the development of PNH; however, the underlying mechanism remains unclear. Therefore, a comprehensive understanding of the underlying mechanisms of PNH is critical for advancing research and developing novel therapeutic strategies. Based on the latest findings, we systematically reviewed the current understanding of PHN mechanisms and corresponding treatment options and provided a comprehensive reference for future studies.

Indexed as

Neuralgia, PostherpeticAnimalsAntiviral AgentsHerpes ZosterHumansAntiviral Agentsdrug therapyHerpes zosterlatent infectionneural circuitneuropathic painpathogenesis

Identifiers

PMID41147274
PMCPMC13519577

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.