Evidence map›Paper›PMID 41147110›Full record

ArticleChembiochem : a European journal of chemical biology2025

A Non-G-Quadruplex Hemin Aptamer Forms a Better Peroxidase Mimicking DNAzyme.

Claudia Rodríguez-Almazán, Yunus A Kaiyum, Philip E Johnson, Juewen Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. A Non-G-Quadruplex Hemin Aptamer Forms a Better Peroxidase Mimicking DNAzyme.Chembiochem : a European journal of chemical biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Claudia Rodríguez-AlmazánDepartment of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, N2L 3G1, Ontario, Canada.
Yunus A KaiyumDepartment of Chemistry, York University, 4700 Keele Street., Toronto, M3J 1P3, Ontario, Canada.
Philip E JohnsonDepartment of Chemistry, York University, 4700 Keele Street., Toronto, M3J 1P3, Ontario, Canada.
Juewen LiuDepartment of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, N2L 3G1, Ontario, Canada.ORCID https://orcid.org/0000-0001-5918-9336

Funding

Canada Research ChairsNatural Sciences and Engineering Research Council of CanadaPrograma de Apoyos para la Superación del Personal Académico
6 · The paper itself

Abstract

G-quadruplex DNA is known to bind to hemin, forming a complex that exhibits peroxidase-like activity. A non-G-quadruplex aptamer named Hem1-2T also exhibits horseradish peroxidase (HRP) like activity upon binding to hemin. Herein, the catalytic characteristics of the Hem1-2T aptamer are studied and compared with PS2.M, an extensively studied G-quadruplex. From pH 6-8, the activity of Hem1-2T decreases with the increase in pH, which is similar to HRP, whereas the activity of PS2.M increases with pH, suggesting that Hem1-2T might be a better mechanistic mimic of HRP. Additionally, Hem1-2T is more effective at protecting hemin from degradation by H

Indexed as

Aptamers, NucleotideBiomimetic MaterialsDNA, CatalyticHeminPeroxidasePeroxidasesG-QuadruplexesHydrogen-Ion ConcentrationHydrogen PeroxideAptamers, NucleotideDNA, CatalyticHeminHydrogen PeroxidePeroxidasePeroxidases2,2′‐azino‐bis (3‐ethylbenzothiazoline‐6‐sulfonic acid)aptamerG‐quadruplexheminperoxidases

Identifiers

PMID41147110
PMCPMC12666243

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.