ArticleCureus2025
Small Lymphocytic Lymphoma/Chronic Lymphocytic Leukemia Presenting as a Nasopharyngeal Mass With Bilateral Otitis Media With Effusion: A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Nasopharyngeal mass containing B-cell small lymphocytic lymphoma in a human immunodeficiency virus-positive patient: A case report and review of the literature.International journal of immunopathology and pharmacologyReview
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL) is an indolent B-cell malignancy that rarely involves the nasopharynx. Such cases may present with nonspecific ear, nose, and throat (ENT) symptoms, delaying diagnosis. In this case report, we present a 54-year-old male who presented with a six-month history of nasal obstruction and bilateral hearing loss due to otitis media with effusion. Nasoendoscopy demonstrated a nasopharyngeal mass. He underwent biopsy and excision of the nasopharyngeal mass, bilateral myringotomy with grommet tube insertion, and turbinoplasty. Histology and immunohistochemistry (IHC) confirmed SLL/CLL. Positron emission tomography (PET)/ computed tomography (CT) showed cervical, axillary, and inguinal lymphadenopathy. Molecular studies found an immunoglobulin heavy chain variable mutation (IGHV) with wild-type TP53. The patient was started on Zanubrutinib 160 mg twice daily, resulting in a rapid resolution of symptoms. SLL and CLL presenting as a nasopharyngeal mass are very rare and can be challenging for ENT experts. Adults with persistent otitis media with effusion (OME) and a nasopharyngeal mass should undergo biopsy with IHC and molecular testing to avoid underdiagnosis and ensure timely targeted therapy.
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